ArticleBMC pharmacology2004
Gender comparison in a murine model of allergen-driven airway inflammation and the response to budesonide treatment.
Article in BMC pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 68 citations in OpenAlex.
- The testosterone paradox in asthma.Frontiers in allergy · 2026Review
- Sex Differences in Lung B Cell Responses in a Murine Model of Asthma.International archives of allergy and immunology · 2026Article
- Dictamnine Exhibits Anti-Asthmatic Effects by Modulating TGF-β/Smad2/3 Signaling in a Murine Asthma Model and Human Bronchial Epithelial Cells.International journal of molecular sciences · 2025Article
- Sex-specific alterations in the gut and lung microbiome of allergen-induced mice.Frontiers in allergy · 2024Article
- More airway smooth muscle in males versus females in a mouse model of asthma: A blessing in disguise?Experimental physiology · 2023Article
- Characterization of sex-related differences in allergen house dust mite-challenged airway inflammation, in two different strains of mice.Scientific reports · 2022Article
- Perimenstrual Asthma in Adolescents: A Shared Condition in Pediatric and Gynecological Endocrinology.Children (Basel, Switzerland) · 2022Review
- Sex Disparities in Asthma Development and Clinical Outcomes: Implications for Treatment Strategies.Journal of asthma and allergy · 2022Review
- Allergen Exposure in Murine Neonates Promoted the Development of Asthmatic Lungs.Biomedicines · 2021Article
- Barrier Housing and Gender Effects on Allergic Airway Disease in a Murine House Dust Mite Model.ImmunoHorizons · 2021Article
- Sex Hormones and Lung Inflammation.Advances in experimental medicine and biology · 2021Article
- Sex-Steroid Signaling in Lung Diseases and Inflammation.Advances in experimental medicine and biology · 2021Article
- Probiotics against airway allergy: host factors to consider.Disease models & mechanisms · 2018Review
- Characterization of a novel model incorporating airway epithelial damage and related fibrosis to the pathogenesis of asthma.Laboratory investigation; a journal of technical methods and pathology · 2014Article
- Article
- Sex and inflammation in respiratory diseases: a clinical viewpoint.Biology of sex differences · 2013Review
- Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Sex differences and sex steroids in lung health and disease.Endocrine reviews · 2012Review
- Role of female sex hormones, estradiol and progesterone, in mast cell behavior.Frontiers in immunology · 2012Article
- Sexual dimorphism in lung function responses to acute influenza A infection.Influenza and other respiratory viruses · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence suggests that gender differences exist in the severity of many immunological diseases and their response to glucocorticosteroid treatment. In this report, we have used a murine model of ovalbumin-induced lung inflammation to address whether gender could affect the systemic response, airway inflammation and hyperreactivity and their responses to budesonide.
resultsFollowing an acute ovalbumin challenge, actively sensitised BALB/c mice developed a time-dependent increase in interleukin-4 and interleukin-5 production and inflammatory cell influx into bronchoalveolar lavage fluid. Apart from an increased number of lymphocytes in female mice at day 3 post-challenge, none of the above parameters were affected by gender. Blood leukocyte numbers were also unaffected, whereas a two-fold increase in total serum immunoglobulin E was observed in female mice. Budesonide, given intranasally, did not affect the blood parameters, but dose-dependently inhibited the pulmonary inflammation and airway hyperreactivity in both male and female mice. Female mice were slightly less sensitive to budesonide's inhibitory action on interleukin-5 production and the development of airway hyperreactivity.
conclusionsOur results suggest that, apart from a 2-fold increase in serum immunoglobulin E levels observed in female mice, gender is not a major factor in the present murine model of ovalbumin-induced lung inflammation. In contrast, gender might slightly influence the potency of test compounds such as steroids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.