ArticleNucleic acids research1992
Intronic sequence with both negative and positive effects on the regulation of alternative transcripts of the chicken beta tropomyosin transcripts.
Article in Nucleic acids research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- The polypyrimidine tract binding protein (PTB) represses splicing of exon 6B from the beta-tropomyosin pre-mRNA by directly interfering with the binding of the U2AF65 subunit.Molecular and cellular biology · 2006Article
- An intronic enhancer regulates splicing of the twintron of Drosophila melanogaster prospero pre-mRNA by two different spliceosomes.Molecular and cellular biology · 2004Article
- Finding signals that regulate alternative splicing in the post-genomic era.Genome biology · 2002Review
- The RNA-binding protein TIA-1 is a novel mammalian splicing regulator acting through intron sequences adjacent to a 5' splice site.Molecular and cellular biology · 2000Article
- Splicing enhancement in the yeast rp51b intron.RNA (New York, N.Y.) · 2000Article
- Combinatorial control of a neuron-specific exon.RNA (New York, N.Y.) · 1999Article
- hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells.Molecular and cellular biology · 1999Article
- An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing.Molecular and cellular biology · 1998Article
- A complex intronic splicing enhancer from the c-src pre-mRNA activates inclusion of a heterologous exon.Molecular and cellular biology · 1997Article
- Multiple interdependent sequence elements control splicing of a fibroblast growth factor receptor 2 alternative exon.Molecular and cellular biology · 1997Article
- The polypyrimidine tract binding protein binds upstream of neural cell-specific c-src exon N1 to repress the splicing of the intron downstream.Molecular and cellular biology · 1997Article
- The SR splicing factors ASF/SF2 and SC35 have antagonistic effects on intronic enhancer-dependent splicing of the beta-tropomyosin alternative exon 6A.The EMBO journal · 1997Article
- Muscle-specific splicing enhancers regulate inclusion of the cardiac troponin T alternative exon in embryonic skeletal muscle.Molecular and cellular biology · 1996Article
- The exon sequence TAGG can inhibit splicing.Nucleic acids research · 1996Article
- Exon and intron sequences, respectively, repress and activate splicing of a fibroblast growth factor receptor 2 alternative exon.Molecular and cellular biology · 1995Article
- Cooperation of 5' and 3' processing sites as well as intron and exon sequences in calcitonin exon recognition.Nucleic acids research · 1995Article
- Regulation of acetylcholine receptor alpha subunit variants in human myasthenia gravis. Quantification of steady-state levels of messenger RNA in muscle biopsy using the polymerase chain reaction.The Journal of clinical investigation · 1994Article
- cis-elements involved in alternative splicing in the rat beta-tropomyosin gene: the 3'-splice site of the skeletal muscle exon 7 is the major site of blockage in nonmuscle cells.Nucleic acids research · 1993Article
- Evolution of protamine P1 genes in primates.Journal of molecular evolution · 1993Article
- cis-acting sequences involved in exon selection in the chicken beta-tropomyosin gene.Molecular and cellular biology · 1992Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The chicken beta tropomyosin gene generates three major transcripts by alternative splicing. A pair of internal exons are spliced in a mutually exclusive manner and their utilisation is developmentally regulated. Exon 6A and exon 6B are used respectively in myoblasts and myotubes during the process of differentiation of muscle cells. We have previously reported that, in myoblasts, exon 6B is skipped because of a negative regulation which involves intron as well as exon sequences. In this report, we describe a previously uncharacterized intronic element which is involved in the regulation of the splicing of both exons 6A and 6B. This cis-element is localized 37nt downstream of exon 6A and is approximately 30nt long. Its deletion, as well as modification of its sequence, results in the activation of the use of exon 6B and, at the same time, in the inhibition of the use of exon 6A. The mechanisms by which this region could act are further discussed.
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