ReviewMarine biotechnology (New York, N.Y.)
Sustainable production of bioactive compounds by sponges--cell culture and gene cluster approach: a review.
Review in Marine biotechnology (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 81 citations in OpenAlex.
- Ethanolic extracts from deep marine sponges: A new frontier in antibacterial discovery from the Jordanian Gulf of Aqaba.Biomedical reports · 2026Article
- Profiling Prokaryotic Communities and Aaptamines of Sponge Aaptos suberitoides from Tulamben, Bali.Marine biotechnology (New York, N.Y.) · 2023Article
- Review
- Identification of Sponge-Associated Bacteria From the Coast of Kuwait and Their Potential Biotechnological Applications.Frontiers in microbiology · 2022Article
- The Distribution and Antibacterial Activity of Marine Sponge-Associated Bacteria in the Aegean Sea and the Sea of Marmara, Turkey.Current microbiology · 2021Article
- Siphonocholin isolated from red sea spongeSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020Article
- Natural products against cancer: Review on phytochemicals from marine sources in preventing cancer.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019Review
- Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the "Supply Problem".Marine drugs · 2016Review
- Marine sponge derived natural products between 2001 and 2010: trends and opportunities for discovery of bioactives.Marine drugs · 2014Review
- Concise total synthesis of two marine natural nucleosides: trachycladines A and B.Beilstein journal of organic chemistry · 2014Article
- Mariculture and natural production of the antitumoural (+)-discodermolide by the Caribbean marine sponge Discodermia dissoluta.Marine biotechnology (New York, N.Y.) · 2013Article
- Synthetic strategies to terpene quinones/hydroquinones.Marine drugs · 2012Review
- Exploring the links between natural products and bacterial assemblages in the sponge Aplysina aerophoba.Applied and environmental microbiology · 2011Article
- Isolation and characterization of a Mn(II)-oxidizing Bacillus strain from the demosponge Suberites domuncula.Marine drugs · 2010Article
- Antiviral lead compounds from marine sponges.Marine drugs · 2010Review
- Marine drugs from sponge-microbe association--a review.Marine drugs · 2010Review
- Monitoring bacterial diversity of the marine sponge Ircinia strobilina upon transfer into aquaculture.Applied and environmental microbiology · 2008Article
- Changes in bacterial communities of the marine sponge Mycale laxissima on transfer into aquaculture.Applied and environmental microbiology · 2008Article
- Nature's bounty - drug discovery from the sea.Expert opinion on drug discovery · 2007Article
- Sponge-associated microorganisms: evolution, ecology, and biotechnological potential.Microbiology and molecular biology reviews : MMBR · 2007Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sponges (phylum Porifera) are sessile marine filter feeders that have developed efficient defense mechanisms against foreign attackers such as viruses, bacteria, or eukaryotic organisms. Protected by a highly complex immune system, as well as by the capacity to produce efficient antiviral compounds (e.g., nucleoside analogues), antimicrobial compounds (e.g., polyketides), and cytostatic compounds (e.g., avarol), they have not become extinct during the last 600 million years. It can be assumed that during this long period of time, bacteria and microorganisms coevolved with sponges, and thus acquired a complex common metabolism. It is suggested that (at least) some of the bioactive secondary metabolites isolated from sponges are produced by functional enzyme clusters, which originated from the sponges and their associated microorganisms. As a consequence, both the host cells and the microorganisms lost the ability to grow independently from each other. Therefore, it was--until recently--impossible to culture sponge cells in vitro. Also the predominant number of "symbiotic bacteria" proved to be nonculturable. In order to exploit the bioactive potential of both the sponge and the "symbionts," a 3D-aggregate primmorph culture system was established; also it was proved that one bioactive compound, avarol/avarone, is produced by the sponge Dysidea avara. Another promising way to utilize the bioactive potential of the microorganisms is the cloning and heterologous expression of enzymes involved in secondary metabolism, such as the polyketide synthases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.