Trial reportIntensive care medicine2004
Combined skin disinfection with chlorhexidine/propanol and aqueous povidone-iodine reduces bacterial colonisation of central venous catheters.
Trial report in Intensive care medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Chlorhexidine vs Povidone-Iodine and Incidence of Catheter-Related Infections: A Systematic Review and Meta-Analysis.JAMA network open · 2026Pooled it
- Skin antisepsis for reducing central venous catheter-related infections.The Cochrane database of systematic reviews · 2016Pooled it
- Pooled it
- epic2: National evidence-based guidelines for preventing healthcare-associated infections in NHS hospitals in England.The Journal of hospital infection · 2007Guideline
- Review
- A state of the art review on optimal practices to prevent, recognize, and manage complications associated with intravascular devices in the critically ill.Intensive care medicine · 2018Review
- Central line-associated bloodstream infections in the intensive care unit: importance of the care bundle.Korean journal of anesthesiology · 2016Article
- Systematic Review and Meta-Analysis of Preoperative Antisepsis with Combination Chlorhexidine and Povidone-Iodine.Surgery journal (New York, N.Y.) · 2016Article
- Does chlorhexidine and povidone-iodine preoperative antisepsis reduce surgical site infection in cranial neurosurgery?Annals of the Royal College of Surgeons of England · 2016Article
- Effect of chlorhexidine pretreatment on bacterial contamination at rhinoplasty field.SpringerPlus · 2016Article
- Endophthalmitis following intravitreal anti-vascular endothelial growth factor (VEGF) injection: a comprehensive review.International journal of retina and vitreous · 2015Review
- A prospective randomised trial to compare the efficacy of povidone-iodine 10% and chlorhexidine 2% for skin disinfection.Indian journal of anaesthesia · 2013Article
- Reduction in catheter-related bloodstream infections in critically ill patients through a multiple system intervention.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2010Article
- Prophylaxis of catheter-related bacteremia using tissue plasminogen activator-tobramycin locks.Pediatric nephrology (Berlin, Germany) · 2009Article
- Chlorhexidine-based antiseptic solutions effectively reduce catheter-related bacteremia.Pediatric nephrology (Berlin, Germany) · 2009Article
- Risk factors and prognosis of catheter-related bloodstream infection in critically ill patients: a multicenter study.Intensive care medicine · 2008Article
- Penetration of chlorhexidine into human skin.Antimicrobial agents and chemotherapy · 2008Article
- [Infection control measures and surveillance of patients with ventricular assist devices].Der Anaesthesist · 2007Review
- Infectious complications of percutaneous central venous catheterization in pediatric patients: a Spanish multicenter study.Intensive care medicine · 2007Article
- Year in review in intensive care medicine, 2004. I. Respiratory failure, infection, and sepsis.Intensive care medicine · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCentral venous catheter (CVC)-related infections may be caused by micro-organisms introduced from the skin surface into deeper tissue at the time of CVC insertion. The optimal disinfection regimen to avoid catheter-related infections has not yet been defined. This study compares three different approaches.
designProspective randomised trial.
settingA tertiary care hospital. PATIENTS AND
participantsOne hundred nineteen patients scheduled electively to receive 140 CVCs.
interventionsSkin disinfection was performed with either povidone-iodine 10% (PVP-iodine), chlorhexidine 0.5%/propanol 70%, or chlorhexidine 0.5%/propanol 70% followed by PVP-iodine 10%. Prior to disinfection, a swab from the site of insertion was taken for culture. CVCs were removed if no longer needed or infection was suspected. All catheters were cultured quantitatively after removal. MEASUREMENT AND
resultsBacteria could be isolated from 20.7% of the catheter tips. Bacterial growth was found in 30.8% of the catheters placed after skin disinfection with povidone-iodine, in 24.4% after disinfection with propanol/chlorhexidine and in 4.7% after disinfection with propanol/chlorhexidine followed by povidone-iodine ( p=0.006). In 15 cases, the same organism was isolated from the skin swab and the catheter tip. Ten of these paired isolates showed the same pattern in a pulsed-field gel electrophoresis analysis.
conclusionsSkin disinfection with propanol/chlorhexidine followed by PVP-iodine was superior in the prevention of microbial CVC colonisation compared to either of the regimens alone. These results support the concept that catheter infections can originate from bacterial translocation at the time of catheter insertion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.