ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Passive or active immunization with myelin basic protein impairs neurological function and exacerbates neuropathology after spinal cord injury in rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 134 citations in OpenAlex.
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- Peripheral immunosuppressive and immunostimulatory signatures of severity and pain in spinal cord injury.Journal of neuroinflammation · 2026Article
- Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications.Burns & trauma · 2023Review
- Review
- L-Arginine Depletion Improves Spinal Cord Injury via Immunomodulation and Nitric Oxide Reduction.Biomedicines · 2022Article
- Gene Therapy Approach with an Emphasis on Growth Factors: Theoretical and Clinical Outcomes in Neurodegenerative Diseases.Molecular neurobiology · 2022Review
- Active and Passive Immunization with Myelin Basic Protein as a Method for Early Treatment of Traumatic Spinal Cord Injury; a Meta-Analysis.Archives of academic emergency medicine · 2021Review
- CD4+ T cell expression of the IL-10 receptor is necessary for facial motoneuron survival after axotomy.Journal of neuroinflammation · 2020Article
- Human immune cells infiltrate the spinal cord and impair recovery after spinal cord injury in humanized mice.Scientific reports · 2019Article
- The non-psychoactive phytocannabinoid cannabidiol (CBD) attenuates pro-inflammatory mediators, T cell infiltration, and thermal sensitivity following spinal cord injury in mice.Cellular immunology · 2018Article
- CNS repair and axon regeneration: Using genetic variation to determine mechanisms.Experimental neurology · 2017Review
- Rat models of spinal cord injury: from pathology to potential therapies.Disease models & mechanisms · 2016Review
- Expression of aryl hydrocarbon receptor in rat brain lesions following traumatic brain injury.Diagnostic pathology · 2016Article
- Neonatal vaccination with bacille Calmette-Guérin promotes the dendritic development of hippocampal neurons.Human vaccines & immunotherapeutics · 2016Article
- T cell deficiency in spinal cord injury: altered locomotor recovery and whole-genome transcriptional analysis.BMC neuroscience · 2015Article
- MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4.The Journal of clinical investigation · 2015Article
- Lewis, Fischer 344, and sprague-dawley rats display differences in lipid peroxidation, motor recovery, and rubrospinal tract preservation after spinal cord injury.Frontiers in neurology · 2015Article
- Regulatory T cells in central nervous system injury: a double-edged sword.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.Journal of neuroscience research · 2013Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myelin-reactive T-cells are activated by traumatic spinal cord injury (SCI) in rodents and humans. Despite the historical association of these cells with experimental and clinical neuropathology, recent data suggest a neuroprotective role for myelin-reactive T-cells. Because of the biological and therapeutic implications of these findings, we attempted to reproduce the original neuroprotective vaccine protocols in a model of rat SCI. Specifically, MBP-reactive T-cell function was enhanced in SCI rats via passive or active immunization. Locomotor function was assessed using a standardized locomotor rating scale (Basso-Beattie-Bresnahan scale) and was correlated with myelin and axon sparing. The functional and anatomical integrity of the rubrospinal pathway also was analyzed using the inclined plane test and anatomical tract tracing. MBP-immunized rats exhibited varying degrees of functional impairment, exacerbated lesion pathology, greater rubrospinal neuron loss, increased intraspinal T-cell accumulation, and enhanced macrophage activation relative to SCI control groups. These data are consistent with the conventional view of myelin-reactive T-cells as pathological effector cells.
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