ArticleBreast cancer research : BCR2004
A screen for germline mutations in the gene encoding CCCTC-binding factor (CTCF) in familial non-BRCA1/BRCA2 breast cancer.
Article in Breast cancer research : BCR, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 17 citations in OpenAlex.
- Enhanced performance of gene expression predictive models with protein-mediated spatial chromatin interactions.Scientific reports · 2023Article
- Enhanced performance of gene expression predictive models with protein-mediated spatial chromatin interactions.bioRxiv : the preprint server for biology · 2023Article
- Review
- CTCF and CTCFL in cancer.Current opinion in genetics & development · 2020Review
- Functional roles of CTCF in breast cancer.BMB reports · 2017Article
- Epigenetic boundaries of tumour suppressor gene promoters: the CTCF connection and its role in carcinogenesis.Journal of cellular and molecular medicineReview
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3 authors at 1 institution in 1 country.
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Abstract
introductionThe CCCTC-binding factor (CTCF), known as a versatile transcription factor and chromatin insulator and to be involved in X inactivation, has also been suggested to be a tumour suppressor on 16q. We investigated 153 patients with familial non-BRCA1/BRCA2 breast cancer for germline mutations in the CTCF gene.
methodsMutation screening of CTCF was performed by denaturing high-performance liquid chromatography followed by cycle sequencing.
resultsWe found two sequence variants, 240G-->A in the 5' untranslated region and 1455C-->T (S388S) in exon 4, in five familial breast cancer cases. Three of these five cases had both variants. Cases and controls showed the same prevalence for the two variants, which were found in linkage disequilibrium in most cases and controls.
conclusionThe present study suggests that germline mutations in CTCF are not important as a risk factor for breast cancer.
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