ArticleBreast cancer research : BCR2004
Molecular analysis of metastasis in a polyomavirus middle T mouse model: the role of osteopontin.
Article in Breast cancer research : BCR, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 52 citations in OpenAlex.
- The cardio-oncologic burden of breast cancer: molecular mechanisms and importance of preclinical models.Basic research in cardiology · 2025Review
- Live tumor imaging shows macrophage induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination.Nature communications · 2021Article
- Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge.NPJ breast cancer · 2021Review
- Understanding the molecular association between hyperkalemia and lung squamous cell carcinomas.BMC medical genetics · 2020Article
- A Syngeneic ErbB2 Mammary Cancer Model for Preclinical Immunotherapy Trials.Journal of mammary gland biology and neoplasia · 2019Article
- Role of Transglutaminase 2 in Migration of Tumor Cells and How Mouse Models Fit.Medical sciences (Basel, Switzerland) · 2018Review
- Immunocompetent mouse allograft models for development of therapies to target breast cancer metastasis.Oncotarget · 2017Article
- CXCR3 as a molecular target in breast cancer metastasis: inhibition of tumor cell migration and promotion of host anti-tumor immunity.Oncotarget · 2015Article
- CCL9 Induced by TGFβ Signaling in Myeloid Cells Enhances Tumor Cell Survival in the Premetastatic Organ.Cancer research · 2015Article
- Attenuated transforming growth factor beta signaling promotes metastasis in a model of HER2 mammary carcinogenesis.Breast cancer research : BCR · 2014Article
- Role of TGF-β signaling in generation of CD39+CD73+ myeloid cells in tumors.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Tumor microenvironment regulates metastasis and metastasis genes of mouse MMTV-PymT mammary cancer cells in vivo.Veterinary pathology · 2014Article
- Role of Rip2 in development of tumor-infiltrating MDSCs and bladder cancer metastasis.PloS one · 2014Article
- TGF-β signaling in myeloid cells is required for tumor metastasis.Cancer discovery · 2013Article
- Transgenic mammary epithelial osteopontin (spp1) expression induces proliferation and alveologenesis.Genes & cancer · 2013Article
- Gr-1+CD11b+ cells are responsible for tumor promoting effect of TGF-β in breast cancer progression.International journal of cancer · 2012Article
- Establishment of clonal MIN-O transplant lines for molecular imaging via lentiviral transduction & in vitro culture.PloS one · 2012Article
- Hepatitis B virus X protein drives multiple cross-talk cascade loops involving NF-κB, 5-LOX, OPN and Capn4 to promote cell migration.PloS one · 2012Article
- TGF-β receptor II loss promotes mammary carcinoma progression by Th17 dependent mechanisms.Cancer discovery · 2011Article
- Osteopontin as a potential biomarker of proliferation and invasiveness for lung cancer.Journal of cancer research and clinical oncology · 2011Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
introductionIn order to study metastatic disease, we employed the use of two related polyomavirus middle T transgenic mouse tumor transplant models of mammary carcinoma (termed Met and Db) that display significant differences in metastatic potential.
methodsThrough suppression subtractive hybridization coupled to the microarray, we found osteopontin (OPN) to be a highly expressed gene in the tumors of the metastatic mouse model, and a lowly expressed gene in the tumors of the lowly metastatic mouse model. We further analyzed the role of OPN in this model by examining sense and antisense constructs using in vitro and in vivo methods.
resultsWith in vivo metastasis assays, the antisense Met cells showed no metastatic tumor formation to the lungs of recipient mice, while wild-type Met cells, with higher levels of OPN, showed significant amounts of metastasis. The Db cells showed a significantly reduced metastasis rate in the in vivo metastasis assay as compared with the Met cells. Db cells with enforced overexpression of OPN showed elevated levels of OPN but did not demonstrate an increase in the rate of metastasis compared with the wild-type Db cells.
conclusionsWe conclude that OPN is an essential regulator of the metastatic phenotype seen in polyomavirus middle T-induced mammary tumors. Yet OPN expression alone is not sufficient to cause metastasis. These data suggest a link between metastasis and phosphatidylinositol-3-kinase-mediated transcriptional upregulation of OPN, but additional phosphatidylinositol-3-kinase-regulated genes may be essential in precipitating the metastasis phenotype in the polyomavirus middle T model.
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