ReviewRespiratory research2004
Bronchospasm and its biophysical basis in airway smooth muscle.
Review in Respiratory research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 66 citations in OpenAlex.
- Effect of Dexamethasone and Fluticasone on Airway Hyperresponsiveness in Horses With Inflammatory Airway Disease.Journal of veterinary internal medicine · 2017Trial
- Article
- Starving a Cell Promotes Airway Smooth Muscle Relaxation: Inhibition of Glycolysis Attenuates Excitation-Contraction Coupling.American journal of respiratory cell and molecular biology · 2023Article
- Asthma: A Loss of Post-natal Homeostatic Control of Airways Smooth Muscle With Regression Toward a Pre-natal State.Frontiers in pediatrics · 2020Review
- The Aftermath of Bronchoconstriction.Journal of engineering and science in medical diagnostics and therapy · 2019Review
- Optogenetic control of cellular forces and mechanotransduction.Nature communications · 2017Article
- Evaluation of pharmacological relaxation effect of the natural product naringin onBiomedical reports · 2016Article
- Measurement of intraindividual airway tone heterogeneity and its importance in asthma.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- CD38 and airway hyper-responsiveness: studies on human airway smooth muscle cells and mouse models.Canadian journal of physiology and pharmacology · 2015Review
- Article
- Ethanol attenuates contraction of primary cultured rat airway smooth muscle cells.American journal of respiratory cell and molecular biology · 2010Article
- MEK modulates force-fluctuation-induced relengthening of canine tracheal smooth muscle.The European respiratory journal · 2010Article
- Shenmai injection inhibiting the extracellular signal regulated kinase-induced human airway smooth muscle proliferation in asthma.Chinese journal of integrative medicine · 2010Article
- Actin polymerization in differentiated vascular smooth muscle cells requires vasodilator-stimulated phosphoprotein.American journal of physiology. Cell physiology · 2010Article
- Acid aspiration-induced airways hyperresponsiveness in mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
- Alteration of airway responsiveness mediated by receptors in ovalbumin-induced asthmatic E3 rats.Acta pharmacologica Sinica · 2009Article
- Alcohol feeding blocks methacholine-induced airway responsiveness in mice.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- Airway smooth muscle and bronchospasm: fluctuating, fluidizing, freezing.Respiratory physiology & neurobiology · 2008Review
- Strange dynamics of a dynamic cytoskeleton.Proceedings of the American Thoracic Society · 2008Review
- Airway hyperresponsiveness, remodeling, and smooth muscle mass: right answer, wrong reason?American journal of respiratory cell and molecular biology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Airways hyperresponsiveness is a cardinal feature of asthma but remains unexplained. In asthma, the airway smooth muscle cell is the key end-effector of bronchospasm and acute airway narrowing, but in just the past five years our understanding of the relationship of responsiveness to muscle biophysics has dramatically changed. It has become well established, for example, that muscle length is equilibrated dynamically rather than statically, and that non-classical features of muscle biophysics come to the forefront, including unanticipated interactions between the muscle and its time-varying load, as well as the ability of the muscle cell to adapt rapidly to changes in its dynamic microenvironment. These newly discovered phenomena have been described empirically, but a mechanistic basis to explain them is only beginning to emerge.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.