ArticleThe Biochemical journal2004
Molecular analysis of muskelin identifies a conserved discoidin-like domain that contributes to protein self-association.
Article in The Biochemical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- The many faces of the GID/CTLH E3 ligase complex.Biochemical Society transactions · 2025Review
- Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases.FEBS letters · 2025Review
- A Missense Variant inGenes · 2021Article
- Novel splice isoforms of pig myoneurin and their diverse mRNA expression patterns.Asian-Australasian journal of animal sciences · 2018Article
- MKLN1 splicing defect in dogs with lethal acrodermatitis.PLoS genetics · 2018Article
- The Cdk5 activator P39 specifically links muskelin to myosin II and regulates stress fiber formation and actin organization in lens.Experimental cell research · 2015Article
- Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics.Nature reviews. Neuroscience · 2013Review
- Article
- Characterization of the novel interaction between muskelin and TBX20, a critical cardiogenic transcription factor.Biochemical and biophysical research communications · 2011Article
- Regulation of IkappaBalpha function and NF-kappaB signaling: AEBP1 is a novel proinflammatory mediator in macrophages.Mediators of inflammation · 2010Review
- Novel role of the muskelin-RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation.The Journal of cell biology · 2008Article
- Neuronal expression of muskelin in the rodent central nervous system.BMC neuroscience · 2007Article
- Adipocyte enhancer-binding protein-1 promotes macrophage inflammatory responsiveness by up-regulating NF-kappaB via IkappaBalpha negative regulation.Molecular biology of the cell · 2007Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Muskelin is an intracellular protein with a C-terminal kelch-repeat domain that was initially characterized as having functional involvement in cell spreading on the extracellular matrix glycoprotein thrombospondin-1. As one approach to understanding the functional properties of muskelin, we have combined bioinformatic and biochemical studies. Through analysis of a new dataset of eight animal muskelins, we showed that the N-terminal region of the polypeptide corresponds to a predicted discoidin-like domain. This domain architecture is conserved in fungal muskelins and reveals a structural parallel between the muskelins and certain extracellular fungal galactose oxidases, although the phylogeny of the two groups appears distinct. In view of the fact that a number of kelch-repeat proteins have been shown to self-associate, co-immunoprecipitation, protein pull-down assays and studies of cellular localization were carried out with wild-type, deletion mutant and point mutant muskelins to investigate the roles of the discoidin-like and kelch-repeat domains. We obtained evidence for cis- and trans-interactions between the two domains. These studies provide evidence that muskelin self-associates through a head-to-tail mechanism involving the discoidin-like domain.
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Registered trials
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