Trial reportEuropean journal of applied physiology2004
Exploration of myostatin polymorphisms and the angiotensin-converting enzyme insertion/deletion genotype in responses of human muscle to strength training.
Trial report in European journal of applied physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Pooled it
- Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis.PloS one · 2021Pooled it
- Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions.Physiological reviews · 2023Review
- Article
- Article
- An intron variant of the GLI family zinc finger 3 (GLI3) gene differentiates resistance training-induced muscle fiber hypertrophy in younger men.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Whole-exome sequencing and genome-wide association studies identify novel sarcopenia risk genes in Han Chinese.Molecular genetics & genomic medicine · 2020Article
- Evaluation of ACE gene I/D polymorphism in Iranian elite athletes.Advanced biomedical research · 2014Article
- Genome-wide association study identified copy number variants important for appendicular lean mass.PloS one · 2014Article
- Mechanisms governing the health and performance benefits of exercise.British journal of pharmacology · 2013Review
- Genetic aspects of skeletal muscle strength and mass with relevance to sarcopenia.BoneKEy reports · 2012Review
- Molecular genetic studies of gene identification for sarcopenia.Human genetics · 2012Review
- Article
- The ACE gene and human performance: 12 years on.Sports medicine (Auckland, N.Z.) · 2011Review
- The K153R polymorphism in the myostatin gene and muscle power phenotypes in young, non-athletic men.PloS one · 2011Article
- ACTN3 R577X Polymorphism and Neuromuscular Response to Resistance Training.Journal of sports science & medicine · 2011Article
- Association of circulating angiotensin converting enzyme activity with respiratory muscle function in infants.Respiratory research · 2010Article
- Association between ACE D allele and elite short distance swimming.European journal of applied physiology · 2009Article
- Myostatin and follistatin polymorphisms interact with muscle phenotypes and ethnicity.Medicine and science in sports and exercise · 2009Article
- Angiotensin-converting enzyme genotype affects skeletal muscle strength in elite athletes.Journal of sports science & medicine · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study explores the associations between polymorphisms in two candidate genes-myostatin gene (MSTN or GDF8) and angiotensin-converting enzyme (ACE) gene-with interindividual differences in human muscle mass and strength responses to strength training. The MSTN AluI A55T (exon 1), BanII K153R, TaqI E164 K and BstNI P198A (all in exon 2) markers and the ACE insertion (I)/deletion (D) polymorphism were typed in 57 males [22.4 (3.7) years] who participated in a 10-week, high-resistance training program for the elbow flexors. Maximal strength, and maximal isometric and concentric elbow flexor torques were measured at baseline and after training. Information on muscle cross-sectional area of the upper arm was obtained by computer tomography scans. Only one individual was heterozygous for the MSTN BanII K153R variant. No allelic variant was detected at the other MSTN sites in this population. For the ACE I/D polymorphism, no evidence was found for an association of the D or I allele with baseline strength, isometric and concentric torque or arm muscle cross-sectional area [analysis of covariance (ANCOVA) 0.25< P<0.97]. Responses to the strength-training program were not associated with the ACE I/D genotype (ANCOVA 0.057< P<0.70). Borderline significance was found for larger strength gains in dynamic flexion torques for I/I genotypes. This study therefore does not support the hypothesis that an increased muscle fiber hypertrophic effect of strength training is present in D-allele carriers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.