ReviewJournal of mammary gland biology and neoplasia2004
Of mice and Myc: c-Myc and mammary tumorigenesis.
Review in Journal of mammary gland biology and neoplasia, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- MYC dysfunction modulates stemness and tumorigenesis in breast cancer.International journal of biological sciences · 2021Article
- Pregnancy reprograms the epigenome of mammary epithelial cells and blocks the development of premalignant lesions.Nature communications · 2020Article
- Isolation and characterization of adult mammary stem cells from breast cancer-adjacent tissues.Oncology letters · 2017Article
- Targeting RNA polymerase I to treat MYC-driven cancer.Oncogene · 2015Review
- Article
- Human fibroblast reprogramming to pluripotent stem cells regulated by the miR19a/b-PTEN axis.PloS one · 2014Article
- MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunits.Nature cell biology · 2012Article
- c-MYC functions as a molecular switch to alter the response of human mammary epithelial cells to oncostatin M.Cancer research · 2011Article
- TGF-beta signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Gadd45a functions as a promoter or suppressor of breast cancer dependent on the oncogenic stress.Cancer research · 2010Article
- Cell cycle and anti-estrogen effects synergize to regulate cell proliferation and ER target gene expression.PloS one · 2010Article
- Anterior gradient-2 plays a critical role in breast cancer cell growth and survival by modulating cyclin D1, estrogen receptor-alpha and survivin.Breast cancer research : BCR · 2010Article
- Cadmium malignantly transforms normal human breast epithelial cells into a basal-like phenotype.Environmental health perspectives · 2009Article
- Animal models of breast cancer for the study of pathogenesis and therapeutic insights.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2009Review
- Article
- Epigenetic mapping and functional analysis in a breast cancer metastasis model using whole-genome promoter tiling microarrays.Breast cancer research : BCR · 2008Article
- The molecular genetics of breast cancer and targeted therapy.Biologics : targets & therapy · 2007Article
- c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1.Molecular and cellular biology · 2007Article
- Harnessing preclinical mouse models to inform human clinical cancer trials.The Journal of clinical investigation · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The proto-oncogene c- myc is involved in regulating proliferation and apoptosis, and its deregulation via genomic and postgenomic mechanisms, contributes to the development and progression of multiple human cancers, including those of the breast. Deregulated expression of c-Myc also contributes to neoplastic transformation by altering cellular differentiation pathways and by facilitating mutagenesis through induction of genomic instability. Transgenic and gene-knockout mice are frequently utilized to resolve the mechanisms through which specific genes influence the development and progression of malignancies. In this review, we discuss how research findings obtained from various c- myc transgenic mammary tumor models help to improve our resolution of c-Myc's role both in tumorigenesis of the murine mammary gland and cancer of the human breast.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.