ArticleMolecular and cellular biology2004
The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
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- Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP1.Journal of the Endocrine Society · 2021Article
- Understanding the role of integrins in breast cancer invasion, metastasis, angiogenesis, and drug resistance.Oncogene · 2021Review
- The small GTPase RhoU lays downstream of JAK/STAT signaling and mediates cell migration in multiple myeloma.Blood cancer journal · 2018Article
- ARF Confers a Context-Dependent Response to Chemotherapy in Muscle-Invasive Bladder Cancer.Cancer research · 2017Article
- Fas Activated Serine-Threonine Kinase Domains 2 (FASTKD2) mediates apoptosis of breast and prostate cancer cells through its novel FAST2 domain.BMC cancer · 2014Article
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- Evidence for a genomic mechanism of action for progesterone receptor membrane component-1.Steroids · 2012Review
- Genome-wide linkage and copy number variation analysis reveals 710 kb duplication on chromosome 1p31.3 responsible for autosomal dominant omphalocele.Journal of medical genetics · 2012Article
- Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G(0)/G(1) Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2.Molecular and cellular biology · 2011Article
- WWOX expression in colorectal cancer--a real-time quantitative RT-PCR study.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2011Article
- Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells.Cancer research · 2009Article
- Comprehensive annotation of bidirectional promoters identifies co-regulation among breast and ovarian cancer genes.PLoS computational biology · 2007Article
- Identification of novel VHL targets that are associated with the development of renal cell carcinoma.Oncogene · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Many anticancer drugs kill cancer cells by inducing apoptosis. Despite the progress in understanding apoptosis, how to harness the cellular death machinery to selectively deliver tumor-specific cytotoxicity (while minimizing damage to other cells) remains an important challenge. We report here that expression of the NRIF3 family of transcriptional coregulators in a variety of breast cancer cell lines induces rapid and profound apoptosis (nearly 100% cell death within 24 h). A novel death domain (DD1) was mapped to a short 30-amino-acid region common to all members of the NRIF3 family. Mechanistic studies showed that DD1-induced apoptosis occurs through a novel caspase 2-mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. Interestingly, the cytotoxicity of NRIF3 and DD1 appears to be cell type specific, as they selectively kill breast cancer or related cells but not other examined cells of different origins. Our study demonstrates the feasibility of selectively inducing cytotoxicity in a specific cancer and suggests that breast cancer cells contain a novel "death switch" that can be specifically triggered by NRIF3 or DD1. Strategies utilizing NRIF3 and/or DD1 and/or targeting this death switch may lead to the development of novel and more selective therapeutics against breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.