ArticleMolecular and cellular biology2004
CREB binds to multiple loci on human chromosome 22.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 168 citations in OpenAlex.
- Multi-faceted regulation of CREB family transcription factors.Frontiers in molecular neuroscience · 2024Review
- Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil.BioMed research international · 2022Article
- RUNX3 Polymorphisms Affect the Risk of Ankylosing Spondylitis.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt.International journal of molecular sciences · 2020Article
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- The transcriptional repressor ICER binds to multiple loci throughout the genome.Biochemical and biophysical research communications · 2016Article
- APOC3 rs2070666 Is Associated with the Hepatic Steatosis Independently of PNPLA3 rs738409 in Chinese Han Patients with Nonalcoholic Fatty Liver Diseases.Digestive diseases and sciences · 2016Article
- Single-Molecule Imaging Reveals Dynamics of CREB Transcription Factor Bound to Its Target Sequence.Scientific reports · 2015Article
- Methamphetamine induces alterations in the long non-coding RNAs expression profile in the nucleus accumbens of the mouse.BMC neuroscience · 2015Article
- Article
- The neuronal activity-driven transcriptome.Molecular neurobiology · 2015Review
- Functional annotation signatures of disease susceptibility loci improve SNP association analysis.BMC genomics · 2014Article
- SIP30 is required for neuropathic pain-evoked aversion in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Article
- A central role for long non-coding RNA in cancer.Frontiers in genetics · 2012Article
- Chromatin immunoprecipitation assay as a tool for analyzing transcription factor activity.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Genetic variants in PNPLA3 and risk of non-alcoholic fatty liver disease in a Han Chinese population.PloS one · 2012Article
- Polymorphisms in inflammasome genes and risk of coal workers' pneumoconiosis in a Chinese population.PloS one · 2012Article
- cAMP response element-binding protein is a primary hub of activity-driven neuronal gene expression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta.Nucleic acids research · 2011Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
The cyclic AMP-responsive element-binding protein (CREB) is an important transcription factor that can be activated by hormonal stimulation and regulates neuronal function and development. An unbiased, global analysis of where CREB binds has not been performed. We have mapped for the first time the binding distribution of CREB along an entire human chromosome. Chromatin immunoprecipitation of CREB-associated DNA and subsequent hybridization of the associated DNA to a genomic DNA microarray containing all of the nonrepetitive DNA of human chromosome 22 revealed 215 binding sites corresponding to 192 different loci and 100 annotated potential gene targets. We found binding near or within many genes involved in signal transduction and neuronal function. We also found that only a small fraction of CREB binding sites lay near well-defined 5' ends of genes; the majority of sites were found elsewhere, including introns and unannotated regions. Several of the latter lay near novel unannotated transcriptionally active regions. Few CREB targets were found near full-length cyclic AMP response element sites; the majority contained shorter versions or close matches to this sequence. Several of the CREB targets were altered in their expression by treatment with forskolin; interestingly, both induced and repressed genes were found. Our results provide novel molecular insights into how CREB mediates its functions in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.