ArticleMolecular and cellular biology2004
A novel protein with similarities to Rb binding protein 2 compensates for loss of Chk1 function and affects histone modification in fission yeast.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Mutation in histone deacetylase clr6 promotes the survival of S. pombe cds1 null mutant in response to hydroxyurea.Molecular genetics and genomics : MGG · 2020Article
- Kinetochore Components Required for Centromeric Chromatin Assembly Are Impacted by Msc1 inGenetics · 2017Article
- Mutant allele of rna14 in fission yeast affects pre-mRNA splicing.Journal of genetics · 2016Article
- Polycomb-dependent nucleolus localization of Jumonji/Jarid2 duringSpermatogenesis · 2016Article
- Article
- Role of swi7H4 mutant allele of DNA polymerase α in the DNA damage checkpoint response.PloS one · 2015Article
- Article
- The oxidative stress responsive transcription factor Pap1 confers DNA damage resistance on checkpoint-deficient fission yeast cells.PloS one · 2014Article
- Activity of a C-terminal plant homeodomain (PHD) of Msc1 is essential for function.The Journal of biological chemistry · 2010Article
- Article
- Histone variant H2A.Z regulates centromere silencing and chromosome segregation in fission yeast.The Journal of biological chemistry · 2010Article
- An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe.Nature structural & molecular biology · 2009Article
- The Schizosaccharomyces pombe JmjC-protein, Msc1, prevents H2A.Z localization in centromeric and subtelomeric chromatin domains.PLoS genetics · 2009Article
- Msc1 links dynamic Swi6/HP1 binding to cell fate determination.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Article
- Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.Genes & development · 2008Review
- Article
- Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment.Genome biology · 2008Article
- Msc1 acts through histone H2A.Z to promote chromosome stability in Schizosaccharomyces pombe.Genetics · 2007Article
- Functional analysis of the transcription repressor PLU-1/JARID1B.Molecular and cellular biology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The conserved protein kinase Chk1 mediates cell cycle progression and consequently the ability of cells to survive when exposed to DNA damaging agents. Cells deficient in Chk1 are hypersensitive to such agents and enter mitosis in the presence of damaged DNA, whereas checkpoint-proficient cells delay mitotic entry to permit time for DNA repair. In a search for proteins that can improve the survival of Chk1-deficient cells exposed to DNA damage, we identified fission yeast Msc1, which is homologous to a mammalian protein that binds to the tumor suppressor Rb (RBP2). Msc1 and RBP2 each possess three PHD fingers, domains commonly found in proteins that influence the structure of chromatin. Msc1 is chromatin associated and coprecipitates a histone deacetylase activity, a property that requires the PHD fingers. Cells lacking Msc1 have a dramatically altered histone acetylation pattern, exhibit a 20-fold increase in global acetylation of histone H3 tails, and are readily killed by trichostatin A, an inhibitor of histone deacetylases. We postulate that Msc1 plays an important role in regulating chromatin structure and that this function modulates the cellular response to DNA damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.