The WHI estrogen-alone trial--do things look any better?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

1. Long-term hormone therapy for perimenopausal and postmenopausal women.The Cochrane database of systematic reviews · 2017
   Pooled it
2. [Role of hormone-replacement therapy for prevention of coronary artery disease in women].Zeitschrift fur Kardiologie · 2005
   Pooled it
3. Association of Menopausal Hormone Therapy With Breast Cancer Incidence and Mortality During Long-term Follow-up of the Women's Health Initiative Randomized Clinical Trials.JAMA · 2020
   Trial
4. Tamoxifen improves cholinergically modulated cognitive performance in postmenopausal women.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013
   Trial
5. Cardiac ventricular Kir6.1 ATP-sensitive potassium channels: an overlooked effector of cardioprotection.Frontiers in physiology · 2026
   Article
6. Impact of Gender-Affirming Hormonal Therapy on Cardiovascular Risk Factors in Transgender Health: An Updated Meta-Analysis.JACC. Advances · 2024
   Article
7. Exploring Hormone Therapy Effects on Reproduction and Health in Transgender Individuals.Medicina (Kaunas, Lithuania) · 2023
   Review
8. Evidence for Menopause as a Sex-Specific Risk Factor for Glaucoma.Cellular and molecular neurobiology · 2023
   Review
9. Comparison of the Efficacy of Tibolone and Transdermal Estrogen in Treating Menopausal Symptoms in Postmenopausal Women.Journal of menopausal medicine · 2019
   Article
10. The Controversial History of Hormone Replacement Therapy.Medicina (Kaunas, Lithuania) · 2019
    Review
11. GPER-novel membrane oestrogen receptor.Clinical science (London, England : 1979) · 2016
    Review
12. Heart disease and hormones.Texas Heart Institute journal · 2011
    Article
13. Self-reported changes in providers' hormone therapy prescribing and counseling practices after the Women's Health Initiative.Journal of women's health (2002) · 2010
    Article
14. Differences in medication use in the Alzheimer's disease neuroimaging initiative: analysis of baseline characteristics.Drugs & aging · 2010
    Article
15. Gender and sex hormones in multiple sclerosis pathology and therapy.Frontiers in bioscience (Landmark edition) · 2009
    Review
16. Hormone use for menopausal symptoms and risk of breast cancer. A Danish cohort study.British journal of cancer · 2005
    Article
17. Adverse neoplastic and cardiovascular outcomes of HRT: the validity of the evidence.Endocrine · 2004
    Review
18. [Evidence based basis of decision making for or against a postmenopausal hormone treatment].Wiener klinische Wochenschrift · 2004
    Article
19. Estrogen, NFkappaB, and the heat shock response.Molecular medicine (Cambridge, Mass.)
    Review
20. The Role of Menopause and Its Association with the Apolipoprotein E4 Allele for Age at Diagnosis of Glaucoma in Women.Ophthalmology science
    Article

Corrections and comments

• Commented on by
  Effects of estrogen-only treatment in postmenopausal women.2004
• Comment on
  Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial.2004

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as