ArticleGenetics2004
The effect of gene conversion on the divergence between duplicated genes.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed.
- Molecular Evolution of the Green-Sensitive Opsins (RH2) in Sulawesi Oryzias Species with a Single Origin.Journal of molecular evolution · 2026Article
- ParaMask: a new method to identify multicopy genomic regions, corrects major biases in whole-genome sequencing data.Genome biology · 2025Article
- Chromatin Topological Domains Associate With the Rapid Formation of Tandem Duplicates in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Concerted evolution reveals co-adapted amino acid substitutions in NaCurrent biology : CB · 2021Article
- The Rubisco small subunits in the green algal genus Chloromonas provide insights into evolutionary loss of the eukaryotic carbon-concentrating organelle, the pyrenoid.BMC ecology and evolution · 2021Article
- Identification of Wild-TypeInsects · 2021Article
- Orthologous Divergence and Paralogous Anticonvergence in Molecular Evolution of Triplicated Green Opsin Genes in Medaka Fish, Genus Oryzias.Genome biology and evolution · 2020Article
- Population Genetics of the Highly PolymorphicGenes · 2019Article
- The Role of Gene Conversion between Transposable Elements in Rewiring Regulatory Networks.Genome biology and evolution · 2019Review
- Gene tree species tree reconciliation with gene conversion.Journal of mathematical biology · 2019Article
- Effect of Collapsed Duplications on Diversity Estimates: What to Expect.Genome biology and evolution · 2018Article
- Morphology, taxonomy and mating-type loci in natural populations of Volvox carteri in Taiwan.Botanical studies · 2018Article
- Article
- Frequent nonallelic gene conversion on the human lineage and its effect on the divergence of gene duplicates.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- SMORE: Synteny Modulator of Repetitive Elements.Life (Basel, Switzerland) · 2017Article
- Reconciliation feasibility in the presence of gene duplication, loss, and coalescence with multiple individuals per species.BMC bioinformatics · 2017Article
- Genome-wide identification of thePeerJ · 2017Article
- Orthologs, turn-over, and remolding of tRNAs in primates and fruit flies.BMC genomics · 2016Article
- Structure and evolutionary history of a large family of NLR proteins in the zebrafish.Open biology · 2016Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonindependent evolution of duplicated genes is called concerted evolution. In this article, we study the evolutionary process of duplicated regions that involves concerted evolution. The model incorporates mutation and gene conversion: the former increases d, the divergence between two duplicated regions, while the latter decreases d. It is demonstrated that the process consists of three phases. Phase I is the time until d reaches its equilibrium value, d(0). In phase II d fluctuates around d(0), and d increases again in phase III. Our simulation results demonstrate that the length of concerted evolution (i.e., phase II) is highly variable, while the lengths of the other two phases are relatively constant. It is also demonstrated that the length of phase II approximately follows an exponential distribution with mean tau, which is a function of many parameters including gene conversion rate and the length of gene conversion tract. On the basis of these findings, we obtain the probability distribution of the level of divergence between a pair of duplicated regions as a function of time, mutation rate, and tau. Finally, we discuss potential problems in genomic data analysis of duplicated genes when it is based on the molecular clock but concerted evolution is common.
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