ArticleGenetics2004
The maintenance of extreme amino acid diversity at the disease resistance gene, RPP13, in Arabidopsis thaliana.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.
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Who cites it
113 citing papers in PubMed.
- Defense against parasites covaries with reproductive timing, not with resistance.PLoS pathogens · 2026Article
- Multilocus genome-wide association study reveals genomic regions associated with resistance to red leaf blotch in soybean.BMC plant biology · 2026Article
- Parasite defense covaries with reproductive timing, not with resistance.bioRxiv : the preprint server for biology · 2026Article
- The adaptive landscape of the miR482 gene family in tomato is rugged.Frontiers in plant science · 2026Article
- Overexpression of a novel CC-NBS-LRR gene NtRPP13 confers enhanced resistance to Ralstonia solanacearum in tobacco.Plant cell reports · 2025Article
- B4 Raf-like MAPKKK RAF24 regulates Arabidopsis thaliana flowering time through HISTONE MONO-UBIQUITINATION 2.The New phytologist · 2025Article
- The resistance awakens: Diversity at the DNA, RNA, and protein levels informs engineering of plant immune receptors from Arabidopsis to crops.The Plant cell · 2025Review
- Single-cell transcriptomic profiling of maize cell heterogeneity and systemic immune responses against Puccinia polysora Underw.Plant biotechnology journal · 2025Article
- Multi-omics analyses reveal the biocontrol potential of endophyticFrontiers in microbiology · 2025Article
- Exploring Distribution and Evolution ofGenes · 2024Article
- Identification of candidate single-nucleotide polymorphisms (SNPs) and genes associated with sugarcane leaf scald disease.Scientific reports · 2024Article
- Identification and functional characterization of theFrontiers in plant science · 2024Article
- Single amino acid change alters specificity of the multi-allelic wheat stem rust resistance locus SR9.Nature communications · 2023Article
- The evolutionary patterns, expression profiles, and genetic diversity of expanded genes in barley.Frontiers in plant science · 2023Article
- Integrating omics reveals that miRNA-guided genetic regulation on plant hormone level and defense response pathways shape resistance toFrontiers in genetics · 2023Article
- ANTHRACNOSE RESISTANCE GENE2 confers fungal resistance in sorghum.The Plant journal : for cell and molecular biology · 2023Article
- Article
- Genetic diversity and disease: The past, present, and future of an old idea.Evolution; international journal of organic evolution · 2022Article
- PM2b, a CC-NBS-LRR protein, interacts with TaWRKY76-D to regulate powdery mildew resistance in common wheat.Frontiers in plant science · 2022Article
- Multiple Sources of Introduction of North American Arabidopsis thaliana from across Eurasia.Molecular biology and evolution · 2021Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We have used the naturally occurring plant-parasite system of Arabidopsis thaliana and its common parasite Peronospora parasitica (downy mildew) to study the evolution of resistance specificity in the host population. DNA sequence of the resistance gene, RPP13, from 24 accessions, including 20 from the United Kingdom, revealed amino acid sequence diversity higher than that of any protein coding gene reported so far in A. thaliana. A significant excess of amino acid polymorphism segregating within this species is localized within the leucine-rich repeat (LRR) domain of RPP13. These results indicate that single alleles of the gene have not swept through the population, but instead, a diverse collection of alleles have been maintained. Transgenic complementation experiments demonstrate functional differences among alleles in their resistance to various pathogen isolates, suggesting that the extreme amino acid polymorphism in RPP13 is maintained through continual reciprocal selection between host and pathogen.
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