ArticleGenetics2004
Functional divergence in tandemly duplicated Arabidopsis thaliana trypsin inhibitor genes.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 50 citations in OpenAlex.
- Genome-Wide Identification and Biotic Stress Responses ofInternational journal of molecular sciences · 2025Article
- Single-Base Resolution Map of Evolutionary Constraints and Annotation of Conserved Elements across Major Grass Genomes.Genome biology and evolution · 2018Article
- Midgut serine proteases and alternative host plant utilization in Pieris brassicae L.Frontiers in physiology · 2015Article
- DELLA proteins modulate Arabidopsis defences induced in response to caterpillar herbivory.Journal of experimental botany · 2014Article
- Intraspecific sequence variation and differential expression in starch synthase genes of Arabidopsis thaliana.BMC research notes · 2013Article
- A species-specific cluster of defensin-like genes encodes diffusible pollen tube attractants in Arabidopsis.PLoS biology · 2012Article
- Alanine substitutions of noncysteine residues in the cysteine-stabilized alphabeta motif.Protein science : a publication of the Protein Society · 2009Article
- Unique genes in plants: specificities and conserved features throughout evolution.BMC evolutionary biology · 2008Article
- Caterpillar saliva interferes with induced Arabidopsis thaliana defence responses via the systemic acquired resistance pathway.Journal of experimental botany · 2008Article
- Unique nucleotide polymorphism of ankyrin gene cluster in Arabidopsis.Journal of genetics · 2007Article
- Arabidopsis-insect interactions.The arabidopsis book · 2007Article
- Molecular evolution of a small gene family of wound inducible Kunitz trypsin inhibitors in Populus.Journal of molecular evolution · 2006Article
- A systematic search for positive selection in higher plants (Embryophytes).BMC plant biology · 2006Article
- Exploratory integration of peanut genetic and physical maps and possible contributions from Arabidopsis.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2005Article
- A multilocus sequence survey in Arabidopsis thaliana reveals a genome-wide departure from a neutral model of DNA sequence polymorphism.Genetics · 2005Article
- Allele-specific assay reveals functional variation in the chalcone synthase promoter of Arabidopsis thaliana that is compatible with neutral evolution.The Plant cell · 2005Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In multigene families, variation among loci and alleles can contribute to trait evolution. We explored patterns of functional and genetic variation in six duplicated Arabidopsis thaliana trypsin inhibitor (ATTI) loci. We demonstrate significant variation in constitutive and herbivore-induced transcription among ATTI loci that show, on average, 65% sequence divergence. Significant variation in ATTI expression was also found between two molecularly defined haplotype classes. Population genetic analyses for 17 accessions of A. thaliana showed that six ATTI loci arranged in tandem within 10 kb varied 10-fold in nucleotide diversity, from 0.0009 to 0.0110, and identified a minimum of six recombination events throughout the tandem array. We observed a significant peak in nucleotide and indel polymorphism spanning ATTI loci in the interior of the array, due primarily to divergence between the two haplotype classes. Significant deviation from the neutral equilibrium model for individual genes was interpreted within the context of intergene linkage disequilibrium and correlated patterns of functional differentiation. In contrast to the outcrosser Arabidopsis lyrata for which recombination is observed even within ATTI loci, our data suggest that response to selection was slowed in the inbreeding, annual A. thaliana because of interference among functionally divergent ATTI loci.
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