ArticleGenetics2004
Isolation and characterization of Y chromosome sequences from the African malaria mosquito Anopheles gambiae.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Copy Number Variation-Based Molecular Sexing ofbioRxiv : the preprint server for biology · 2025Article
- Sex-specific transcriptome dynamics ofGenes & development · 2025Article
- Duplex PCR assay to determine sex and mating status of Ixodes scapularis (Acari: Ixodidae), vector of the Lyme disease pathogen.Journal of medical entomology · 2025Article
- Patterns of Gene Flow inEvolutionary applications · 2024Article
- A confinable female-lethal population suppression system in the malaria vector,Science advances · 2023Article
- Article
- Characterization of the First W-Specific Protein-Coding Gene for Sex Identification inFrontiers in genetics · 2020Article
- Current versus future reproductive investment adaptive responses in adult Anopheles coluzzii malaria mosquitoes: hydric-stressed males give it all.Parasites & vectors · 2019Article
- An investigation of Y chromosome incorporations in 400 species of Drosophila and related genera.PLoS genetics · 2018Article
- Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- First report of Y-linked genes in the kissing bug Rhodnius prolixus.BMC genomics · 2016Article
- Dosage Compensation in the African Malaria Mosquito Anopheles gambiae.Genome biology and evolution · 2016Article
- Heterosis Increases Fertility, Fecundity, and Survival of Laboratory-Produced F1 Hybrid Males of the Malaria Mosquito Anopheles coluzzii.G3 (Bethesda, Md.) · 2015Article
- Genome-Wide Search Identifies 1.9 Mb from the Polar Bear Y Chromosome for Evolutionary Analyses.Genome biology and evolution · 2015Article
- The germline of the malaria mosquito produces abundant miRNAs, endo-siRNAs, piRNAs and 29-nt small RNAs.BMC genomics · 2015Article
- Site-specific genetic engineering of the Anopheles gambiae Y chromosome.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Insights into the preservation of the homomorphic sex-determining chromosome of Aedes aegypti from the discovery of a male-biased gene tightly linked to the M-locus.Genome biology and evolution · 2014Article
- Efficient identification of Y chromosome sequences in the human and Drosophila genomes.Genome research · 2013Article
- A unique Y gene in the Asian malaria mosquito Anopheles stephensi encodes a small lysine-rich protein and is transcribed at the onset of embryonic development.Insect molecular biology · 2013Article
- Six novel Y chromosome genes in Anopheles mosquitoes discovered by independently sequencing males and females.BMC genomics · 2013Article
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Authors and funding
4 authors.
Funding
Abstract
The karyotype of the African malaria mosquito Anopheles gambiae contains two pairs of autosomes and a pair of sex chromosomes. The Y chromosome, constituting approximately 10% of the genome, remains virtually unexplored, despite the recent completion of the A. gambiae genome project. Here we report the identification and characterization of Y chromosome sequences of total length approaching 150 kb. We developed 11 Y-specific PCR markers that consistently yielded male-specific products in specimens from both laboratory colony and natural populations. The markers are characterized by low sequence polymorphism in samples collected across Africa and by presence in more than one copy on the Y. Screening of the A. gambiae BAC library using these markers allowed detection of 90 Y-linked BAC clones. Analysis of the BAC sequences and other Y-derived fragments showed massive accumulation of a few transposable elements. Nevertheless, more complex sequences are apparently present on the Y; these include portions of an approximately 48-kb-long unmapped AAAB01008227 scaffold from the whole genome shotgun assembly. Anopheles Y appears not to harbor any of the genes identified in Drosophila Y. However, experiments suggest that one of the ORFs from the AAAB01008227 scaffold represents a fragment of a gene with male-specific expression.
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