ArticleGenetics2004
Mutation accumulation in populations of varying size: the distribution of mutational effects for fitness correlates in Caenorhabditis elegans.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 116 citations in OpenAlex.
- Evolvability: progress and key questions.Bioscience · 2025Review
- Outcrossing Complicates Mutation Purging by Trapping Single Nucleotide Polymorphisms in Structural Variant Mutations.bioRxiv : the preprint server for biology · 2025Article
- Hill-Robertson interference may bias the inference of fitness effects of new mutations in highly selfing species.Evolution; international journal of organic evolution · 2025Article
- Article
- Hill-Robertson interference may bias the inference of fitness effects of new mutations in highly selfing species.bioRxiv : the preprint server for biology · 2024Article
- Are mutations usually deleterious? A perspective on the fitness effects of mutation accumulation.Evolutionary ecology · 2022Article
- Selection in a growing colony biases results of mutation accumulation experiments.Scientific reports · 2022Article
- Causes of variability in estimates of mutational variance from mutation accumulation experiments.Genetics · 2022Article
- Long-term experimental evolution reveals purifying selection on piRNA-mediated control of transposable element expression.BMC biology · 2020Article
- Competitive fitness analysis using Convolutional Neural Network.Journal of nematology · 2020Article
- Partial Selfing Can Reduce Genetic Loads While Maintaining Diversity During Experimental Evolution.G3 (Bethesda, Md.) · 2019Article
- Mutational Landscape of Spontaneous Base Substitutions and Small Indels in ExperimentalGenetics · 2019Article
- Sex and Mitonuclear Adaptation in ExperimentalGenetics · 2019Article
- Hierarchical Assessment of Mutation Properties inG3 (Bethesda, Md.) · 2018Article
- Article
- Adaptive Evolution under Extreme Genetic Drift in Oxidatively Stressed Caenorhabditis elegans.Genome biology and evolution · 2017Article
- The evolutionary trade-off between stem cell niche size, aging, and tumorigenesis.Evolutionary applications · 2017Article
- Experimental Evolution withGenetics · 2017Review
- The Fitness Effects of Spontaneous Mutations Nearly Unseen by Selection in a Bacterium with Multiple Chromosomes.Genetics · 2016Article
- Adaptation to Temporally Fluctuating Environments by the Evolution of Maternal Effects.PLoS biology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The consequences of mutation for population-genetic and evolutionary processes depend on the rate and, especially, the frequency distribution of mutational effects on fitness. We sought to approximate the form of the distribution of mutational effects by conducting divergence experiments in which lines of a DNA repair-deficient strain of Caenorhabditis elegans, msh-2, were maintained at a range of population sizes. Assays of these lines conducted in parallel with the ancestral control suggest that the mutational variance is dominated by contributions from highly detrimental mutations. This was evidenced by the ability of all but the smallest population-size treatments to maintain relatively high levels of mean fitness even under the 100-fold increase in mutational pressure caused by knocking out the msh-2 gene. However, we show that the mean fitness decline experienced by larger populations is actually greater than expected on the basis of our estimates of mutational parameters, which could be consistent with the existence of a common class of mutations with small individual effects. Further, comparison of the total mutation rate estimated from direct sequencing of DNA to that detected from phenotypic analyses implies the existence of a large class of evolutionarily relevant mutations with no measurable effect on laboratory fitness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.