ArticleGenes & development2004
BRU1, a novel link between responses to DNA damage and epigenetic gene silencing in Arabidopsis.
Article in Genes & development, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
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96 citing papers in PubMed, 219 citations in OpenAlex.
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- TONSOKU prevents the formation of large tandem duplications and restrains ATR-WEE1 checkpoint activation.Nature communications · 2026Article
- Direct recruitment of TONSOKU by the N-terminal tails of histone variants H2A.X and H2A.W coordinates DNA repair.Science advances · 2025Article
- H3.1K27M-induced misregulation of the TONSOKU-H3.1 pathway causes genomic instability.Nature communications · 2025Article
- Regulation of heterochromatin organization in plants.Journal of plant research · 2024Review
- Photoperiod-1 regulates the wheat inflorescence transcriptome to influence spikelet architecture and flowering time.Current biology : CB · 2024Article
- Pungency related gene network in Allium sativum L., response to sulfur treatments.BMC genomic data · 2024Article
- Role of Epigenetic Factors in Response to Stress and Establishment of Somatic Memory of Stress Exposure in Plants.Plants (Basel, Switzerland) · 2023Review
- Mitotic inheritance of genetic and epigenetic information via the histone H3.1 variant.Current opinion in plant biology · 2023Review
- RTEL1 is required for silencing and epigenome stability.Nucleic acids research · 2023Article
- Linking transcriptional silencing with chromatin remodeling, folding, and positioning in the nucleus.Current opinion in plant biology · 2022Review
- The Role of the TSK/TONSL-H3.1 Pathway in Maintaining Genome Stability in Multicellular Eukaryotes.International journal of molecular sciences · 2022Review
- The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication.Science (New York, N.Y.) · 2022Article
- The role of ATXR6 expression in modulating genome stability and transposable element repression inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- The plant stem-cell niche and pluripotency: 15 years of an epigenetic perspective.Frontiers in plant science · 2022Article
- Thermo-Priming Mediated Cellular Networks for Abiotic Stress Management in Plants.Frontiers in plant science · 2022Review
- An insight into understanding the coupling between homologous recombination mediated DNA repair and chromatin remodeling mechanisms in plant genome: an update.Cell cycle (Georgetown, Tex.) · 2021Review
- A cluster of Ankyrin and Ankyrin-TPR repeat genes is associated with panicle branching diversity in rice.PLoS genetics · 2021Article
- Epigenetic regulation of abiotic stress memory: maintaining the good things while they last.Current opinion in plant biology · 2021Review
- Phyllotaxis: from classical knowledge to molecular genetics.Journal of plant research · 2021Review
36 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA repair associated with DNA replication is important for the conservation of genomic sequence information, whereas reconstitution of chromatin after replication sustains epigenetic information. We have isolated and characterized mutations in the BRU1 gene of Arabidopsis that suggest a novel link between these underlying maintenance mechanisms. Bru1 plants are highly sensitive to genotoxic stress and show stochastic release of transcriptional gene silencing. They also show increased intrachromosomal homologous recombination and constitutively activated expression of poly (ADP-ribose) polymerase-2 (AtPARP-2), the induction of which is associated with elevated DNA damage. Bru1 mutations affect the stability of heterochromatin organization but do not interfere with genome-wide DNA methylation. BRU1 encodes a novel nuclear protein with two predicted protein-protein interaction domains. The developmental abnormalities characteristic of bru1 mutant plants resemble those triggered by mutations in genes encoding subunits of chromatin assembly factor (CAF-1), the condensin complex, or MRE11. Comparison of bru1 with these mutants indicates cooperative roles in the replication and stabilization of chromatin structure, providing a novel link between chromatin replication, epigenetic inheritance, S-phase DNA damage checkpoints, and the regulation of meristem development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.