ArticleAnnals of the rheumatic diseases2004
Increased transendothelial migration of scleroderma lymphocytes.
Article in Annals of the rheumatic diseases, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Cardiac involvement in systemic sclerosis: mechanisms, manifestations and management.Rheumatology (Oxford, England) · 2026Review
- ITGAL as a prognostic biomarker correlated with immune infiltrates in melanoma.Frontiers in oncology · 2023Article
- T-Cell Adhesion in Healthy and Inflamed Skin.JID innovations : skin science from molecules to population health · 2021Review
- Comparative analysis of affected and unaffected areas of systemic sclerosis skin biopsies by high-throughput proteomic approaches.Arthritis research & therapy · 2020Article
- Subset-specific alterations in frequencies and functional signatures of γδ T cells in systemic sclerosis patients.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Epigenetics and systemic sclerosis.Seminars in immunopathology · 2015Review
- Hypomethylation and overexpression of ITGAL (CD11a) in CD4(+) T cells in systemic sclerosis.Clinical epigenetics · 2014Article
- The pathogenesis of systemic sclerosis revisited.Clinical reviews in allergy & immunology · 2011Review
- Penile involvement in Systemic Sclerosis: New Diagnostic and Therapeutic Aspects.International journal of rheumatology · 2010Article
- T cells and B cells in the pathogenesis of systemic sclerosis: recent insights and therapeutic opportunities.Current rheumatology reports · 2006Review
- Alpha4beta1 and alpha4beta7 CD4 T cell numbers increase and CLA CD4 T cell numbers decrease in systemic sclerosis.Clinical and experimental immunology · 2005Article
- Local hyperemia to heating is impaired in secondary Raynaud's phenomenon.Arthritis research & therapy · 2005Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCD4+ T lymphocytes play an important part in the pathogenesis of scleroderma (systemic sclerosis, SSc) and predominate in perivascular SSc skin lesions. Both soluble and membrane bound adhesion molecules are overexpressed in SSc, possibly influencing lymphocyte/endothelial cell (EC) contact.
objectiveTo assess the transendothelial migration capacity of peripheral lymphocytes in vitro. PATIENTS AND
methodsCollagen was covered with human umbilical vein endothelial cells (HUVEC), and peripheral blood mononuclear cells (PBMC) of patients and matched healthy controls (HC) were added in parallel experiments. Before and after fractionated harvest of non-adherent, bound, and migrated lymphocytes, the CD4/CD8 ratio and the lymphocytic expression of activation markers and adhesion molecules were analysed by fluorocytometry.
results13 (SD 12)% of the SSc PBMC migrated compared with only 5 (5)% HC PBMC (p<0.0002); this increase was primarily due to the migration of CD3+ T lymphocytes and mainly to a larger proportion of CD4+ cells within this CD3+ fraction (71 (SD 14)% for SSc v 56 (14)% for HC, p<0.03), leading to an increased CD4/CD8 ratio among migrated SSc lymphocytes in comparison with controls (3.3 (1.5) v 1.62 (0.93), p<0.006). Among migrated SSc CD4+ T lymphocytes, the frequency of HLA-DR+ cells was increased; migrated lymphocytes highly expressed the adhesion molecules CD11a, CD49d, CD29, and CD44.
conclusionTransendothelial migration of CD4+ T lymphocytes is enhanced in SSc, and migrating cells exhibit an activated phenotype. The data suggest that activated CD3+CD4+ lymphocytes as found in SSc peripheral blood are prone to transvascular migration, thus contributing to the formation of typical perivascular lymphocytic infiltrates.
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