Trial reportBMJ (Clinical research ed.)2004
Randomised controlled factorial trial of dietary advice for patients with a single high blood pressure reading in primary care.
Trial report in BMJ (Clinical research ed.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 15 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 15 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Effectiveness of salt substitute on cardiovascular outcomes: A systematic review and meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2022Pooled it
- Replacing salt with low-sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women.The Cochrane database of systematic reviews · 2022Pooled it
- Association between the Urinary Sodium to Potassium Ratio and Blood Pressure in Adults: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- Healthcare professional-led interventions on lifestyle modifications for hypertensive patients - a systematic review and meta-analysis.BMC family practice · 2021Pooled it
- Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020Pooled it
- Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020Pooled it
- Effects of total fat intake on body weight.The Cochrane database of systematic reviews · 2015Pooled it
- Behavioural weight management programmes for adults assessed by trials conducted in everyday contexts: systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2014Pooled it
- Pooled it
- Effectiveness of dietary interventions among adults of retirement age: a systematic review and meta-analysis of randomized controlled trials.BMC medicine · 2014Pooled it
- Dietary advice for reducing cardiovascular risk.The Cochrane database of systematic reviews · 2013Pooled it
- Nurse delivered lifestyle interventions in primary health care to treat chronic disease risk factors associated with obesity: a systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2012Pooled it
- Reduced or modified dietary fat for preventing cardiovascular disease.The Cochrane database of systematic reviews · 2012Pooled it
- Reduced or modified dietary fat for preventing cardiovascular disease.The Cochrane database of systematic reviews · 2011Pooled it
- Multiple risk factor interventions for primary prevention of coronary heart disease.The Cochrane database of systematic reviews · 2011Pooled it
- Effectiveness of Written Dietary Advice for Improving Blood Lipids in Primary Care Adults-A Pragmatic Randomized Controlled Trial (MYDICLIN).Nutrients · 2022Trial
- Long-term effects of salt substitution on blood pressure in a rural north Chinese population.Journal of human hypertension · 2013Trial
- Effectiveness of five different approaches in management of urinary tract infection: randomised controlled trial.BMJ (Clinical research ed.) · 2010Trial
- Efficacy of a brief image-based multiple-behavior intervention for college students.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2008Trial
- A randomised trial of a 5 week, manual based, self-management programme for hypertension delivered in a cardiac patient club in Shanghai.BMC cardiovascular disorders · 2008Trial
Corrections and comments
- Commented on by
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the effect of brief interventions during the "watchful waiting" period for hypertension.
designFactorial trial.
settingGeneral practice.
methods296 patients with blood pressure > 160/90 mm Hg were randomised to eight groups defined by three factors: an information booklet; low sodium, high potassium salt; prompt sheets for high fruit, vegetable, fibre; and low fat.
main outcome measuresBlood pressure (primary outcome); secondary outcomes of diet, weight, and dietary biomarkers (urinary sodium:potassium (Na:K) ratio; carotenoid concentrations).
resultsBlood pressure was not affected by the booklet (mean difference (diastolic blood pressure) at one month 0.2, 95% confidence interval 1.6 to 2.0), salt (0.13; 1.7 to 2.0), or prompts (0.52; 1.3 to 2.4). The salt decreased Na:K ratio (difference 0.32; 0.08 to 0.56, P = 0.01), and the prompts helped control weight (difference 0.39 (0.85 to 0.05) kg at one month, P = 0.085; 1.2 (0.1 to 2.25) kg at six months, P = 0.03). Among those with lower fruit and vegetable consumption (< 300 g per day), prompts increased fruit and vegetable consumption and also carotenoid concentrations (difference 143 (16 to 269) mmol/l, P < 0.03) but did not decrease blood pressure.
conclusionDuring watchful waiting, over and above the effect of brief advice and monitoring, an information booklet, lifestyle prompts, and low sodium salt do not reduce blood pressure. Secondary analysis suggests that brief interventions-particularly lifestyle prompts-can make useful changes in diet and help control weight, which previous research indicates are likely to reduce the long term risk of stroke.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.