ArticleMolecular and cellular biology1992
Functional antagonism between YY1 and the serum response factor.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
62 citing papers in PubMed, 163 citations in OpenAlex.
- SRF: a seriously responsible factor in cardiac development and disease.Journal of biomedical science · 2022Review
- A proximity-based graph clustering method for the identification and application of transcription factor clusters.BMC bioinformatics · 2017Article
- Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis.Nucleic acids research · 2017Article
- Regulation of Yin Yang 1 by Tyrosine Phosphorylation.The Journal of biological chemistry · 2015Article
- miR-411 is up-regulated in FSHD myoblasts and suppresses myogenic factors.Orphanet journal of rare diseases · 2013Article
- Sphingosine-1-phosphate and endothelin-1 induce the expression of rgs16 protein in cardiac myocytes by transcriptional activation of the rgs16 gene.Naunyn-Schmiedeberg's archives of pharmacology · 2008Article
- The inflammatory and normal transcriptome of mouse bladder detrusor and mucosa.BMC physiology · 2006Article
- Binding of serum response factor to cystic fibrosis transmembrane conductance regulator CArG-like elements, as a new potential CFTR transcriptional regulation pathway.Nucleic acids research · 2005Article
- Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin.Molecular and cellular biology · 2005Article
- The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation.Genes & development · 2004Article
- Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter.Molecular and cellular biology · 2004Article
- Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1.Genes & development · 2003Article
- Transcription factor YY1 functions as a PcG protein in vivo.The EMBO journal · 2003Article
- CArG binding factor A (CBF-A) is involved in transcriptional regulation of the rat Ha-ras promoter.Nucleic acids research · 2000Article
- Activation of the c-fos enhancer by the erk MAP kinase pathway through two sequence elements: the c-fos AP-1 and p62TCF sites.Oncogene · 2000Article
- Increased level and duration of expression in muscle by co-expression of a transactivator using plasmid systems.Gene therapy · 1999Article
- Interaction of Gli2 with CREB protein on DNA elements in the long terminal repeat of human T-cell leukemia virus type 1 is responsible for transcriptional activation by tax protein.Journal of virology · 1999Article
- Regulation of serum amyloid A protein expression during the acute-phase response.The Biochemical journal · 1998Review
- Influence of promoter potency on the transcriptional effects of YY1, SRF and Msx-1 in transient transfection analysis.Nucleic acids research · 1998Article
- TFII-I enhances activation of the c-fos promoter through interactions with upstream elements.Molecular and cellular biology · 1998Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The rapid, transient induction of the c-fos proto-oncogene by serum growth factors is mediated by the serum response element (SRE). The SRE shares homology with the muscle regulatory element (MRE) of the skeletal alpha-actin promoter. It is not known how these elements respond to proliferative and cell-type-specific signals, but the response appears to involve the binding of the serum response factor (SRF) and other proteins. Here, we report that YY1, a multifunctional transcription factor, binds to SRE and MRE sequences in vitro. The methylation interference footprint of YY1 overlaps with that of the SRF, and YY1 competes with the SRF for binding to these DNA elements. Overexpression of YY1 repressed serum-inducible and basal expression from the c-fos promoter and repressed basal expression from the skeletal alpha-actin promoter. YY1 also repressed expression from the individual SRE and MRE sequences upstream from a TATA element. Unlike that of YY1, SRF overexpression alone did not influence the transcriptional activity of the target sequence, but SRF overexpression could reverse YY1-mediated trans repression. These data suggest that YY1 and the SRF have antagonistic functions in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.