ArticleMolecular and cellular biology1992
Drosophila transcriptional repressor protein that binds specifically to negative control elements in fat body enhancers.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 48 citations in OpenAlex.
- Large-scale analysis of Drosophila core promoter function using synthetic promoters.Molecular systems biology · 2022Article
- Article
- Role of co-repressor genomic landscapes in shaping the Notch response.PLoS genetics · 2017Article
- Targeting gene expression to the female larval fat body of transgenic Aedes aegypti mosquitoes.Insect molecular biology · 2013Article
- Functional diversification of sonic hedgehog paralog enhancers identified by phylogenomic reconstruction.Genome biology · 2007Article
- Sex-, stage- and tissue-specific regulation by a mosquito hexamerin promoter.Insect molecular biology · 2006Article
- The regulation of yp3 expression in the Drosophila melanogaster fat body.Development genes and evolution · 2003Article
- A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Evidence for redundancy but not trans factor-cis element coevolution in the regulation of Drosophila Yp genes.Genetics · 1999Article
- Regulation of Drosophila Adh promoter switching by an initiator-targeted repression mechanism.The EMBO journal · 1998Article
- Synpolydactyly phenotypes correlate with size of expansions in HOXD13 polyalanine tract.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Three protein binding sites form an enhancer that regulates sex- and fat body-specific transcription of Drosophila yolk protein genes.The EMBO journal · 1995Article
- Mapping and mutagenesis of the amino-terminal transcriptional repression domain of the Drosophila Krüppel protein.Molecular and cellular biology · 1994Article
- Redundant cis-acting elements control expression of the Drosophila affinidisjuncta Adh gene in the larval fat body.Nucleic acids research · 1994Article
- Deletion scanning of the regulatory sequences of the Fbp1 gene of Drosophila melanogaster using P transposase-induced deficiencies.Genetics · 1993Article
- Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins.Nucleic acids research · 1993Article
- Characterization and mapping of the human SOX4 gene.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
Expression of the Drosophila melanogaster Adh gene in adults requires a fat body-specific enhancer called the Adh adult enhancer (AAE). We have identified a protein in Drosophila nuclear extracts that binds specifically to a site within the AAE (adult enhancer factor 1 [AEF-1]). In addition, we have shown that AEF-1 binds specifically to two other Drosophila fat body enhancers. Base substitutions in the AEF-1 binding site that disrupt AEF-1 binding in vitro result in a significant increase in the level of Adh expression in vivo. Thus, the AEF-1 binding site is a negative regulatory element within the AAE. A cDNA encoding the AEF-1 protein was isolated and shown to act as a repressor of the AAE in cotransfection studies. The AEF-1 protein contains four zinc fingers and an alanine-rich sequence. The latter motif is found in other eukaryotic proteins known to be transcriptional repressors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.