ArticleMolecular and cellular biology1992
Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 159 citations in OpenAlex.
- Protein kinase C zeta suppresses low- or high-grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring.The Journal of pathology · 2018Article
- Article
- Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5.PloS one · 2013Article
- Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis.The Journal of biological chemistry · 2011Article
- Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex.Cell death and differentiation · 2009Review
- Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3.Genes & development · 2004Article
- The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta.Molecular and cellular biology · 2002Article
- Atypical protein kinase Cs are the Ras effectors that mediate repression of myogenic satellite cell differentiation.Molecular and cellular biology · 2002Article
- Protein kinase C-delta regulates thrombin-induced ICAM-1 gene expression in endothelial cells via activation of p38 mitogen-activated protein kinase.Molecular and cellular biology · 2001Article
- MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling.Molecular and cellular biology · 2001Article
- Different protein kinase C isoforms determine growth factor specificity in neuronal cells.Molecular and cellular biology · 2000Article
- The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway.The EMBO journal · 2000Article
- The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.The EMBO journal · 1999Article
- p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex.Molecular and cellular biology · 1999Article
- Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein.The Journal of cell biology · 1999Article
- Atypical protein kinase Clambda binds and regulates p70 S6 kinase.The Biochemical journal · 1998Article
- An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3.The Journal of cell biology · 1998Article
- Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.Molecular and cellular biology · 1998Article
- Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade.Molecular and cellular biology · 1997Article
- Protein kinase C isoenzymes in airway smooth muscle.The Biochemical journal · 1997Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of studies have demonstrated the activation of phospholipase C-mediated hydrolysis of phosphatidylcholine (PC-PLC) both by growth factors and by the product of the ras oncogene, p21ras. Evidence has been presented indicating that the stimulation of this phospholipid degradative pathway is sufficient to activate mitogenesis in fibroblasts as well as that it is sufficient and necessary for induction of maturation in Xenopus laevis oocytes. However, the mechanism whereby PC-PLC transduces mitogenic signals triggered by growth factors or oncogenes remains to be elucidated. In this study, data are presented that show the involvement of protein kinase C zeta subspecies in the channelling of the mitogenic signal activated by insulin-p21ras-PC-PLC in Xenopus oocytes as well as the lack of a critical role of protein kinase C isotypes alpha, beta, gamma, delta, and epsilon in these pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.