ArticleProceedings of the National Academy of Sciences of the United States of America2004
Dendritic cells cross-present HIV antigens from live as well as apoptotic infected CD4+ T lymphocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 88 citations in OpenAlex.
- Dendritic cells overcome Cre/Lox induced gene deficiency by siphoning cytosolic material from surrounding cells.iScience · 2024Article
- A secreted Tapasin isoform impairs cytotoxic T lymphocyte recognition by disrupting exogenous MHC class I antigen presentation.Frontiers in immunology · 2024Article
- Pathways of MHC I cross-presentation of exogenous antigens.Seminars in immunology · 2023Review
- Immunomodulatory Effects of Non-Thermal Plasma in a Model for Latent HIV-1 Infection: Implications for an HIV-1-Specific Immunotherapy.Biomedicines · 2023Article
- Vaccine adjuvants to engage the cross-presentation pathway.Frontiers in immunology · 2022Review
- Review
- Myeloid Populations in Systemic Autoimmune Diseases.Clinical reviews in allergy & immunology · 2017Review
- SAMHD1 Limits HIV-1 Antigen Presentation by Monocyte-Derived Dendritic Cells.Journal of virology · 2015Article
- Variable processing and cross-presentation of HIV by dendritic cells and macrophages shapes CTL immunodominance and immune escape.PLoS pathogens · 2015Article
- Transfer of antigen from human B cells to dendritic cells.Molecular immunology · 2014Article
- Priming of CD8(+) T Cell Responses to Liver Stage Malaria Parasite Antigens.Frontiers in immunology · 2014Review
- Antigen cross-presentation by dendritic cell subsets: one general or all sergeants?Trends in immunology · 2013Article
- Effect of malaria on HIV/AIDS transmission and progression.Parasites & vectors · 2013Review
- Inhibition of antigen trafficking through scavenger receptor A.The Journal of biological chemistry · 2012Article
- The Impact of HIV Coinfection on Cerebral Malaria Pathogenesis.Journal of neuroparasitology · 2012Article
- Article
- Exposure to apoptotic activated CD4+ T cells induces maturation and APOBEC3G-mediated inhibition of HIV-1 infection in dendritic cells.PloS one · 2011Article
- Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- A novel cancer vaccine strategy based on HLA-A*0201 matched allogeneic plasmacytoid dendritic cells.PloS one · 2010Article
- Plasmacytoid dendritic cells in HIV infection: striking a delicate balance.Journal of leukocyte biology · 2010Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A better understanding of the antigen presentation pathways that lead to CD8(+) T cell recognition of HIV epitopes in vivo is needed to achieve better immune control of HIV replication. Here, we show that cross-presentation of very small amounts of HIV proteins from apoptotic infected CD4(+) T lymphocytes by dendritic cells to CD8(+) T cells is much more efficient than other known HIV presentation pathways, i.e., direct presentation of infectious virus or cross-presentation of defective virus. Unexpectedly, dendritic cells also take up actively antigens into endosomes from live infected CD4(+) T lymphocytes and cross-present them as efficiently as antigens derived from apoptotic infected cells. Moreover, live infected CD4(+) T cells costimulate cross-presenting dendritic cells in the process. Therefore, dendritic cells can present very small amounts of viral proteins from infected T cells either after apoptosis, which is frequent during HIV infection, or not. Thus, if HIV expression is transiently induced while costimulation is enhanced (for instance after IL-2 and IFNalpha immune therapy), this HIV antigen presentation pathway could be exploited to eradicate latently infected reservoirs, which are poorly recognized by patients' immune systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.