ArticleProceedings of the National Academy of Sciences of the United States of America2004
Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation.The Journal of experimental medicine · 2026Article
- Antigen-specific immunotherapy with a CD4Nature communications · 2026Article
- Tissue-Resident Th2 Cells in Type 2 Immunity and Allergic Diseases.Immunological reviews · 2025Review
- Impact of Viral Lower Respiratory Tract Infection (LRTI) in Early Childhood (0-2 Years) on Lung Growth and Development and Lifelong Trajectories of Pulmonary Health: A National Institutes of Health (NIH) Workshop Summary.Pediatric pulmonology · 2025Review
- Fiber rich food suppressed airway inflammation, GATA3 + Th2 cells, and FcεRIα+ eosinophils in asthma.Frontiers in nutrition · 2024Article
- IL-17A plays a critical role in RSV infection in children and mice.Virology journal · 2023Article
- Lung T cell response in COVID-19.Frontiers in immunology · 2023Review
- Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation.Immunity · 2022Article
- Article
- Resolved Influenza A Virus Infection Has Extended Effects on Lung Homeostasis and Attenuates Allergic Airway Inflammation in a Mouse Model.Microorganisms · 2020Article
- Human lung tissue resident memory T cells in health and disease.Current opinion in immunology · 2019Review
- Bystander T Cells: A Balancing Act of Friends and Foes.Trends in immunology · 2018Review
- Antigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b+ dendritic cells to suppress allergic inflammation.Mucosal immunology · 2016Article
- The sickle cell mouse lung: proinflammatory and primed for allergic inflammation.Translational research : the journal of laboratory and clinical medicine · 2015Article
- Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation.Nature communications · 2015Article
- CD8+ T Cells Mediate Female-Dominant IL-4 Production and Airway Inflammation in Allergic Asthma.PloS one · 2015Article
- Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity.The Journal of clinical investigation · 2011Article
- Macaque proteome response to highly pathogenic avian influenza and 1918 reassortant influenza virus infections.Journal of virology · 2010Article
- Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Innate responsiveness of CD8 memory T-cell populations nonspecifically inhibits allergic sensitization.The Journal of allergy and clinical immunology · 2008Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
CD8+ memory T cells have recently been recognized as playing a key role in natural immunity against unrelated viral infections, a phenomenon referred to as "heterologous antiviral immunity." We now provide data that the cellular immunological interactions that underlie such heterologous immunity can play an equally important role in regulating T helper 2 immune responses and protecting mucosal surfaces from allergen-induced inflammation. Our data show that CD8+ T cells, either retained in the lung after infection with influenza virus, or adoptively transferred via the intranasal route can suppress allergic airway inflammation. The suppression is mediated by IFN-gamma, which acts to reduce the activation level, T helper 2 cytokine production, airways hyperresponsiveness, and migration of allergen-specific CD4+ T cells into the lung, whereas the systemic and draining lymph node responses remain unchanged. Of note, adoptive transfer of previously activated transgenic CD8+ T cells conferred protection against allergic airway inflammation, even in the absence of specific-antigen. Airway resident CD8+ T cells produced IFN-gamma when directly exposed to conditioned media from activated dendritic cells or the proinflammatory cytokines IL-12 and IL-18. Taken together these data indicate that effector/memory CD8+ T cells present in the airways produce IFN-gamma after inflammatory stimuli, independent of specific-antigen, and as a consequence play a key role in modifying the degree and frequency of allergic responses in the lung.
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Registered trials
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