Evidence map›Paper›PMID 15078974›Full record

ArticleJournal of virology2004

Inability of simian virus 40 to establish productive infection of lymphoblastic cell lines.

Sophie Shaikh, Christine Skoczylas, Richard Longnecker, Kathleen Rundell

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sophie ShaikhDepartment of Microbiology-Immunology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA.
Christine Skoczylas
Richard Longnecker
Kathleen Rundell
Northwestern University · US

Funding

In Vivo Model of Epstein-Barr Virus LatencyR01CA073507 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LONGNECKER, RICHARD M · 1997 to 2018
$6.1M
EBV LATENT MEMBRANE PROTEIN 2R01CA062234 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LONGNECKER, RICHARD M · 1994 to 2007
$2.2M
SV40 Small-t Antigen and Human Cell TransformationR01CA021327 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RUNDELL, M KATHLEEN · 1985 to 2006
$1.8M
Functional Studies of gp42 and HLA Class 11 in EBVR01CA093444 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LONGNECKER, RICHARD M · 2002 to 2006
$1.8M
THE ROLE OF EPSTEIN-BARR VIRUS EBNA1, LMP1 AND LMP2A PROR01DE013127 · NIDCR · NORTHWESTERN UNIVERSITY · PI LONGNECKER, RICHARD M · 1999 to 2003
$1.0M
NCI NIH HHS CA21327NCI NIH HHS CA62234NCI NIH HHS CA73507NCI NIH HHS CA93444NCI NIH HHS R01 CA021327NCI NIH HHS R01 CA062234NCI NIH HHS R01 CA073507NCI NIH HHS R01 CA093444NIDCR NIH HHS DE13127NIDCR NIH HHS R01 DE013127
6 · The paper itself

Abstract

Lymphoblastic cell lines were infected with simian virus 40 (SV40) and then monitored for evidence of a productive infection. No evidence of early gene expression was found 2 days following infection, as determined by assaying viral mRNAs and early antigens. Furthermore, only small amounts of virus could be detected by plaque assay 2 days after infection, and levels slowly declined until they were undetectable after a few weeks in culture. Thus, human lymphocytes are not readily infectible with SV40 and do not provide a simple model for studying interactions of SV40 with a human cell type.

Indexed as

Cell LineCell Line, TransformedCell Line, TumorHumansLymphocytesSimian virus 40Viral Plaque Assay

Identifiers

PMID15078974
PMCPMC387682
OpenAlexW2151917126

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.