Evidence map›Paper›PMID 15078971›Full record

ArticleJournal of virology2004

Transduction of terminally differentiated neurons by avian sarcoma virus.

James G Greger, Richard A Katz, Konstantin Taganov, Glenn F Rall, Anna Marie Skalka

Abstract readEvaluation Study
In one paragraph

Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Avian retroviral replication.Current opinion in virology · 2013
    Review
  4. Alpharetroviral vector-mediated gene therapy for X-CGD: functional correction and lack of aberrant splicing.Molecular therapy : the journal of the American Society of Gene Therapy · 2013
    Article
  5. Review
  6. Article
  7. Article
  8. The road to chromatin - nuclear entry of retroviruses.Nature reviews. Microbiology · 2007
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

James G GregerFox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania 19111-2497, USA.
Richard A Katz
Konstantin Taganov
Glenn F Rall
Anna Marie Skalka

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Margaret von Mehren · 1985 to 2026
$138.8M
INTEGRATION OF RETROVIRAL DNA--ACCESSING HOST TARGET DNAR01CA071515 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI KATZ, RICHARD ALAN · 1996 to 2016
$7.6M
STRUCTURE/FUNCTION OF INTEGRASER01AI040385 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI ANDRAKE, MARK DAVID · 1997 to 2016
$7.1M
HIGHER ORDER PROTEIN-DNA COMPLEXES IN GENE REGULATIONR01GM047903 · NIGMS · INSTITUTE FOR CANCER RESEARCH · PI ZARET, KENNETH S. · 1994 to 2005
$1.4M
NCI NIH HHS CA06927NCI NIH HHS CA71515NCI NIH HHS P30 CA006927NCI NIH HHS R01 CA071515NIAID NIH HHS AI40385NIAID NIH HHS R01 AI040385NIGMS NIH HHS GM47903NIGMS NIH HHS R01 GM047903
6 · The paper itself

Abstract

Recent studies have demonstrated that avian sarcoma virus (ASV) can transduce cycle-arrested cells. Here, we have assessed quantitatively the transduction efficiency of an ASV vector in naturally arrested mouse hippocampal neurons. This efficiency was determined by comparing the number of transduced cells after infection of differentiated neurons versus dividing progenitor cells. The results indicate that ASV is able to transduce these differentiated neurons efficiently and that this activity is not the result of infection of residual dividing cells. The transduction efficiency of the ASV vector was found to be intermediate between the relatively high and low efficiencies obtained with human immunodeficiency virus type 1 and murine leukemia virus vectors, respectively.

Indexed as

Transduction, GeneticAnimalsAvian Sarcoma VirusesCell DifferentiationCells, CulturedGenetic VectorsGreen Fluorescent ProteinsHippocampusLuminescent ProteinsMiceNeuronsGreen Fluorescent ProteinsLuminescent Proteins

Identifiers

PMID15078971
PMCPMC387698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.