ArticleEukaryotic cell2004
Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence.
Article in Eukaryotic cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 76 citations in OpenAlex.
- Review
- Cell aggregation mediated bymSphere · 2024Article
- Experimental evolution of multicellularity via cuboidal cell packing in fission yeast.Evolution letters · 2024Article
- Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection.Nature communications · 2024Article
- Strain and temperature dependent aggregation ofCell surface (Amsterdam, Netherlands) · 2023Article
- Recent Advances in Understanding the Human Fungal Pathogen Hypoxia Response in Disease Progression.Annual review of microbiology · 2023Review
- Using Bioluminescence to Image Candida glabrata Urinary Tract Infections in Mice.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Clumping Morphology Influences Virulence Uncoupled from Echinocandin Resistance in Candida glabrata.Microbiology spectrum · 2022Article
- Human albumin enhances the pathogenic potential of Candida glabrata on vaginal epithelial cells.PLoS pathogens · 2021Article
- Roles of Elm1 in antifungal susceptibility and virulence in Candida glabrata.Scientific reports · 2020Article
- Global Secretome Characterization of the Pathogenic YeastJournal of proteome research · 2020Article
- Review
- Amn1 governs post-mitotic cell separation in Saccharomyces cerevisiae.PLoS genetics · 2018Article
- Deletion ofAntimicrobial agents and chemotherapy · 2018Article
- Aspergillus fumigatus virulence through the lens of transcription factors.Medical mycology · 2017Review
- A Small Protein Associated with Fungal Energy Metabolism Affects the Virulence of Cryptococcus neoformans in Mammals.PLoS pathogens · 2016Article
- Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species Comparison.Frontiers in cellular and infection microbiology · 2016Review
- The trans-kingdom identification of negative regulators of pathogen hypervirulence.FEMS microbiology reviews · 2016Review
- One small step for a yeast--microevolution within macrophages renders Candida glabrata hypervirulent due to a single point mutation.PLoS pathogens · 2014Article
- Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes.PLoS pathogens · 2014Article
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
During an infection, the coordinated orchestration of many factors by the invading organism is required for disease to be initiated and to progress. The elucidation of the processes involved is critical to the development of a clear understanding of host-pathogen interactions. For Candida species, the inactivation of many fungal attributes has been shown to result in attenuation. Here we demonstrate that the Candida glabrata homolog of the Saccharomyces cerevisiae transcription factor gene ACE2 encodes a function that mediates virulence in a novel way. Inactivation of C. glabrata ACE2 does not result in attenuation but, conversely, in a strain that is hypervirulent in a murine model of invasive candidiasis. C. glabrata ace2 null mutants cause systemic infections characterized by fungal escape from the vasculature, tissue penetration, proliferation in vivo, and considerable overstimulation of the proinflammatory arm of the innate immune response. Compared to the case with wild-type fungi, mortality occurs much earlier in mice infected with C. glabrata ace2 cells, and furthermore, 200-fold lower doses are required to induce uniformly fatal infections. These data demonstrate that C. glabrata ACE2 encodes a function that plays a critical role in mediating the host-Candida interaction. It is the first virulence-moderating gene to be described for a Candida species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.