ArticleEukaryotic cell2004
Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response.
Article in Eukaryotic cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
65 citing papers in PubMed, 123 citations in OpenAlex.
- Pathogenicity and virulence of Cryptococcus neoformans from an environmental perspective.Virulence · 2025Review
- An unusual Toll/MyD88-mediatedFly · 2024Article
- Accumulation of endogenous free radicals is required to induce titan-like cell formation inmBio · 2024Article
- A Galleria Model of Cryptococcus neoformans Infection.Methods in molecular biology (Clifton, N.J.) · 2024Article
- The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins.EMBO reports · 2023Article
- Lipids as a key element of insect defense systems.Frontiers in genetics · 2023Review
- Infections ofFrontiers in cellular and infection microbiology · 2022Article
- Tobacco Hornworm (Virulence · 2020Article
- A mutation in C. neoformans mitochondrial NADH dehydrogenase results in increased virulence in mice.Virulence · 2020Article
- Advances in Molecular Tools and In Vivo Models for the Study of Human Fungal Pathogenesis.Microorganisms · 2020Review
- Review
- Review
- Volatile Organic Compounds Produced by Human Pathogenic Fungi Are Toxic toFrontiers in fungal biology · 2020Article
- Basic principles of the virulence ofVirulence · 2019Review
- Silkworm as an experimental animal for research on fungal infections.Microbiology and immunology · 2019Review
- Ras signalling in pathogenic yeasts.Microbial cell (Graz, Austria) · 2017Review
- Review
- Nutritional Requirements and Their Importance for Virulence of Pathogenic Cryptococcus Species.Microorganisms · 2017Review
- Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis.Frontiers in microbiology · 2017Review
- Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
We found that the ingestion of Cryptococcus neoformans by Drosophila melanogaster resulted in the death of the fly but that the ingestion of Saccharomyces cerevisiae or the nonpathogenic Cryptococcus kuetzingii or Cryptococcus laurentii did not. The C. neoformans protein kinase A and RAS signal transduction pathways, previously shown to be involved in virulence in mammals, also played a role in killing Drosophila. Mutation of the Toll immune response pathway, the predominant antifungal pathway of the fly, did not play a role in Drosophila defense following ingestion of the yeast. However, the Toll pathway was necessary for the clearance of C. neoformans introduced directly into the hemolymph of D. melanogaster and for the survival of systemically infected flies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.