ArticleEukaryotic cell2004
Novel p-type ATPases mediate high-affinity potassium or sodium uptake in fungi.
Article in Eukaryotic cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 74 citations in OpenAlex.
- Article
- A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma.Nature communications · 2025Article
- Mutational analysis of an antimalarial drug target,Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Mineral-Doped Micromodel Platform Demonstrates Fungal Bridging of Carbon Hot Spots and Hyphal Transport of Mineral-Derived Nutrients.mSystems · 2022Article
- Bioinformatics approaches for classification and investigation of the evolution of the Na/K-ATPase alpha-subunit.BMC ecology and evolution · 2022Article
- Review
- Involvement of Protein Kinase CgSat4 in Potassium Uptake, Cation Tolerance, and Full Virulence inFrontiers in plant science · 2022Article
- The Potassium Transporter Hak1 inJournal of fungi (Basel, Switzerland) · 2021Article
- P-type NaVirulence · 2020Article
- Article
- Trk1, the sole potassium-specific transporter in Candida glabrata, contributes to the proper functioning of various cell processes.World journal of microbiology & biotechnology · 2019Article
- The Role of Soil Fungi in KInternational journal of molecular sciences · 2019Review
- P-type transport ATPases in Leishmania and Trypanosoma.Parasite (Paris, France) · 2019Review
- Fungal spores as a source of sodium salt particles in the Amazon basin.Nature communications · 2018Article
- Potassium Uptake Mediated by Trk1 Is Crucial for Candida glabrata Growth and Fitness.PloS one · 2016Article
- Article
- Plant surface cues prime Ustilago maydis for biotrophic development.PLoS pathogens · 2014Article
- Adaptation to high salt concentrations in halotolerant/halophilic fungi: a molecular perspective.Frontiers in microbiology · 2014Review
- Genome and transcriptome sequencing of the halophilic fungus Wallemia ichthyophaga: haloadaptations present and absent.BMC genomics · 2013Article
- Coordination of K+ transporters in neurospora: TRK1 is scarce and constitutive, while HAK1 is abundant and highly regulated.Eukaryotic cell · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungi have an absolute requirement for K+, but K+ may be partially replaced by Na+. Na+ uptake in Ustilago maydis and Pichia sorbitophila was found to exhibit a fast rate, low Km, and apparent independence of the membrane potential. Searches of sequences with similarity to P-type ATPases in databases allowed us to identify three genes in these species, Umacu1, Umacu2, and PsACU1, that could encode P-type ATPases of a novel type. Deletion of the acu1 and acu2 genes proved that they encoded the transporters that mediated the high-affinity Na+ uptake of U. maydis. Heterologous expressions of the Umacu2 gene in K+ transport mutants of Saccharomyces cerevisiae and transport studies in the single and double Deltaacu1 and Deltaacu2 mutants of U. maydis revealed that the acu1 and acu2 genes encode transporters that mediated high-affinity K+ uptake in addition to Na+ uptake. Other fungi also have genes or pseudogenes whose translated sequences show high similarity to the ACU proteins of U. maydis and P. sorbitophila. In the phylogenetic tree of P-type ATPases all the identified ACU ATPases define a new cluster, which shows the lowest divergence with type IIC, animal Na+,K(+)-ATPases. The fungal high-affinity Na+ uptake mediated by ACU ATPases is functionally identical to the uptake that is mediated by some plant HKT transporters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.