ArticleJournal of neuro-oncology
The expression of survivin and Ki-67 in meningiomas: correlation with grade and clinical outcome.
Article in Journal of neuro-oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Evaluation of Surgical Cleavage Plane by Preoperative Magnetic Resonance Imaging Findings in Adult Intracranial Meningiomas.Life (Basel, Switzerland) · 2022Article
- Clinical features and prognostic factors in spinal meningioma surgery from a multicenter study.Scientific reports · 2021Article
- The anti-apoptotic protein survivin can improve the prognostication of meningioma patients.PloS one · 2017Article
- Long-term recurrence rates after the removal of spinal meningiomas in relation to Simpson grades.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2016Article
- Epigenetic Role of Histone 3 Lysine Methyltransferase and Demethylase in Regulating Apoptosis Predicting the Recurrence of Atypical Meningioma.Journal of Korean medical science · 2015Article
- Serum survivin increases in prolactinoma.Journal of clinical medicine research · 2015Article
- Caspase-3 and survivin expression in primary atypical and malignant meningiomas.ISRN neuroscience · 2013Article
- SPECT and PET imaging of meningiomas.TheScientificWorldJournal · 2012Article
- Signals of apoptotic pathways in several types of meningioma.Pathology oncology research : POR · 2011Article
- Lopinavir inhibits meningioma cell proliferation by Akt independent mechanism.Journal of neuro-oncology · 2011Article
- Survivin as an immunotherapeutic target for adult and pediatric malignant brain tumors.Cancer immunology, immunotherapy : CII · 2010Review
- (99m)Tc-Tetrofosmin brain SPECT in the assessment of meningiomas-correlation with histological grade and proliferation index.Journal of neuro-oncology · 2008Article
- Clinical and radiological features related to the growth potential of meningioma.Neurosurgical review · 2006Article
- Benign tumors from the human nervous system express high levels of survivin and are resistant to spontaneous and radiation-induced apoptosis.Journal of neuro-oncology · 2005Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identification of proteins involving in the control of proliferation in normal cells may lead to a better understanding of cellular transformation and proliferation mechanisms. Measurement of proliferative activity may help determine the tumor grade, recurrence and malignancy. Forty meningiomas of various histological grade, diagnosed in Baskent University and Cukurova University Medical Faculty, Departments of Pathology, were graded according to WHO grading system and survivin and Ki-67 monoclonal antibodies were administered by immunohistochemical method. Findings were analyzed with statistical methods; distribution of survivin expression and Ki-67 LI values were determined for different grade meningiomas. The correlation between increasing grades of meningiomas, particularly between grades I and III, survivin and Ki-67 LI values was statistically significant. In addition, we have found a positive correlation between clinical outcome, survivin and Ki-67 LI. For over expression of survivin in some of the grade I meningiomas and no or mild expression in some of the grades II and III meningiomas, however, it has been suggested that apoptosis inhibited by survivin is not the only factor responsible for progression of meningiomas.
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Registered trials
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