ArticleJournal of neuro-oncology
Functional significance of vascular endothelial growth factor receptor expression on human glioma cells.
Article in Journal of neuro-oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Sequential Treatment with Temozolomide Plus Naturally Derived AT101 as an Alternative Therapeutic Strategy: Insights into Chemoresistance Mechanisms of Surviving Glioblastoma Cells.International journal of molecular sciences · 2023Article
- Article
- A pentapeptide enabled AL3810 liposome-based glioma-targeted therapy with immune opsonic effect attenuated.Acta pharmaceutica Sinica. B · 2021Article
- Review
- Diosgenin as a Novel Alternative Therapy for Inhibition of Growth, Invasion, and Angiogenesis Abilities of Different Glioblastoma Cell Lines.Neurochemical research · 2020Article
- Prognostic significance of VEGF receptors expression on the tumor cells in skull base chordoma.Journal of neuro-oncology · 2019Article
- Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells.International journal of oncology · 2017Article
- Article
- Vascular Endothelial Growth Factor, Irradiation, and Axitinib Have Diverse Effects on Motility and Proliferation of Glioblastoma Multiforme Cells.Frontiers in oncology · 2017Article
- miR-302b suppresses cell invasion and metastasis by directly targeting AKT2 in human hepatocellular carcinoma cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Down regulation of Akirin-2 increases chemosensitivity in human glioblastomas more efficiently than Twist-1.Oncotarget · 2015Article
- MicroRNA-16 inhibits glioma cell growth and invasion through suppression of BCL2 and the nuclear factor-κB1/MMP9 signaling pathway.Cancer science · 2014Article
- Article
- VEGF promotes proliferation of human glioblastoma multiforme stem-like cells through VEGF receptor 2.TheScientificWorldJournal · 2013Article
- Bmi-1 promotes the aggressiveness of glioma via activating the NF-kappaB/MMP-9 signaling pathway.BMC cancer · 2012Article
- Expression of stem cell marker and receptor kinase genes in glioblastoma tissue quantified by real-time RT-PCR.Brain tumor pathology · 2011Article
- Bevacizumab can induce reactivity to VEGF-C and -D in human brain and tumour derived endothelial cells.Journal of neuro-oncology · 2011Article
- Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype.Oncogene · 2008Article
- Angiogenesis in gliomas: imaging and experimental therapeutics.Brain pathology (Zurich, Switzerland) · 2005Review
- Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis.Neuro-oncology · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vascular endothelial growth factor (VEGF) is one of the most important angiogenesis factors. In many tumors, VEGF plays a pivotal role for their vascularization and is necessary to supply the malignant tissue with oxygen and nutrients. However, VEGF receptors (VEGFR) have recently been detected also on some tumor cells, and autocrine mitogenic effects of VEGF have been suspected. Since glioma cells are known to produce large amounts of VEGF, we investigated VEGFR-expression and effects of VEGF on glioma cells. The three glioma cell lines and eight glioma cells cultivated from WHO grade IV gliomas investigated strongly expressed VEGF121 and VEGF165, but weakly either VEGFR-1 or -2, sometimes for both, as evidenced by reverse transcription-polymerase chain reaction (RT-PCR) and immunocytochemistry. Quantitative RT-PCR revealed a 1000- to 50-fold lower expression of VEGFR than in cultivated human umbilical vein endothelial cells. In two glioma cell lines analyzed, VEGF induced a weak tyrosine phosphorylation of the VEGFR, but downstream signal transduction effects on the mitogen-activated protein kinases p42/p44 or transcription factors like AP-1 or NFKB were within the background of the methods. In accordance, VEGF or the VEGFR agonists VEGF-D or placenta growth factor (P1GF) did not produce significant effects on glioma cell proliferation or VEGF production. We conclude that despite a low expression of VEGFR in some glioma cells functional effects are low and autocrine growth stimulatory effects within a glioma are minor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.