ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Odors detected by mice deficient in cyclic nucleotide-gated channel subunit A2 stimulate the main olfactory system.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 141 citations in OpenAlex.
- Ion Channels in Odor Information Processing of Neural Circuits of the Vertebrate Olfactory Bulb.International journal of molecular sciences · 2024Review
- Review
- Renewal and Differentiation of GCD Necklace Olfactory Sensory Neurons.Chemical senses · 2020Article
- HPG-Dependent Peri-Pubertal Regulation of Adult Neurogenesis in Mice.Frontiers in neuroanatomy · 2020Article
- Sense of Smell: Structural, Functional, Mechanistic Advancements and Challenges in Human Olfactory Research.Current neuropharmacology · 2019Article
- Activation of intestinal olfactory receptor stimulates glucagon-like peptide-1 secretion in enteroendocrine cells and attenuates hyperglycemia in type 2 diabetic mice.Scientific reports · 2017Article
- The long tale of the calcium activated ClChannels (Austin, Tex.) · 2017Review
- Grueneberg Glomeruli in the Olfactory Bulb are Activated by Odorants and Cool Temperature.Cellular and molecular neurobiology · 2017Article
- A comparison of the effects of male pheromone priming and optogenetic inhibition of accessory olfactory bulb forebrain inputs on the sexual behavior of estrous female mice.Hormones and behavior · 2017Article
- Dichotomous Distribution of Putative Cholinergic Interneurons in Mouse Accessory Olfactory Bulb.Frontiers in neuroanatomy · 2017Article
- Olfaction and Pheromones: Uncanonical Sensory Influences and Bulbar Interactions.Frontiers in neuroanatomy · 2017Review
- Identification and characterization of cichlid TAAR genes and comparison with other teleost TAAR repertoires.BMC genomics · 2015Article
- Genetic dissection of pheromone processing reveals main olfactory system-mediated social behaviors in mice.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Electrophysiological Evidence for a Direct Link between the Main and Accessory Olfactory Bulbs in the Adult Rat.Frontiers in neuroscience · 2015Article
- Stability and flexibility of the message carried by semiochemical stimuli, as revealed by devaluation of carbon disulfide followed by social transmission of food preference.Behavioral neuroscience · 2014Article
- Transduction for pheromones in the main olfactory epithelium is mediated by the Ca2+ -activated channel TRPM5.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons.Frontiers in cellular neuroscience · 2014Article
- Article
- Either main or accessory olfactory system signaling can mediate the rewarding effects of estrous female chemosignals in sexually naive male mice.Behavioral neuroscience · 2013Article
- An effective manual deboning method to prepare intact mouse nasal tissue with preserved anatomical organization.Journal of visualized experiments : JoVE · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
It is believed that odor transduction in the mammalian main olfactory system only involves the cAMP-signaling pathway. Here, we report on odor responsiveness in mice with a disrupted cyclic nucleotide-gated (CNG) channel subunit A2. Several odorants, including putative pheromones, can be detected and discriminated by these mice behaviorally. These odors elicit responses in the olfactory epithelium, main olfactory bulb, and olfactory (piriform) cortex of CNGA2 knock-out mice. In addition, responses to odors detected by CNGA2 knock-out mice are relatively insensitive to inhibitors of the cAMP pathway. These results provide strong evidence that cAMP-independent pathways in the main olfactory system of mammals participate in detecting a subset of odors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.