ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Hypocretin/orexin innervation and excitation of identified septohippocampal cholinergic neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 142 citations in OpenAlex.
- Functional Plasticity of Orexin/Hypocretin Neurons Balances Stress States.Biological psychiatry · 2026Review
- Empathy and prosocial behavior powered by orexin-driven theta oscillations.Science (New York, N.Y.) · 2026Article
- Evaluation of cellular activity in response to sleep deprivation by a comprehensive analysis of the whole mouse brain.Frontiers in neuroscience · 2023Article
- Review
- Hypocretin/orexin influences chronic sleep disruption injury in the hippocampus.Frontiers in aging neuroscience · 2022Article
- Lithium Enhances the GABAergic Synaptic Activities on the Hypothalamic Preoptic Area (hPOA) Neurons.International journal of molecular sciences · 2021Article
- Orexin-A Intensifies Mouse Pupillary Light Response by Modulating Intrinsically Photosensitive Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Hypothalamus and amygdala functional connectivity at rest in narcolepsy type 1.NeuroImage. Clinical · 2021Article
- Ionic Mechanisms Underlying the Excitatory Effect of Orexin on Rat Subthalamic Nucleus Neurons.Frontiers in cellular neuroscience · 2019Article
- Acetylcholine Release Inhibits Distinct Excitatory Inputs Onto Hippocampal CA1 Pyramidal Neurons via Different Cellular and Network Mechanisms.Frontiers in cellular neuroscience · 2019Article
- Glycinergic Input to the Mouse Basal Forebrain Cholinergic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Orexin Directly Enhances the Excitability of Globus Pallidus Internus Neurons in Rat by Co-activating OX1 and OX2 Receptors.Neuroscience bulletin · 2017Article
- Hypocretin (orexin) is critical in sustaining theta/gamma-rich waking behaviors that drive sleep need.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Descending projections from the basal forebrain to the orexin neurons in mice.The Journal of comparative neurology · 2017Article
- The Input-Output Relationship of the Cholinergic Basal Forebrain.Cell reports · 2017Article
- Basal Forebrain Cholinergic System and Orexin Neurons: Effects on Attention.Frontiers in behavioral neuroscience · 2017Review
- Orexin/Hypocretin and Organizing Principles for a Diversity of Wake-Promoting Neurons in the Brain.Current topics in behavioral neurosciences · 2017Review
- Na(+) -Ca(2+) Exchanger, Leak K(+) Channel and Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Comediate the Histamine-Induced Excitation on Rat Inferior Vestibular Nucleus Neurons.CNS neuroscience & therapeutics · 2016Article
- Dynorphin inhibits basal forebrain cholinergic neurons by pre- and postsynaptic mechanisms.The Journal of physiology · 2016Article
- Turning a Negative into a Positive: Ascending GABAergic Control of Cortical Activation and Arousal.Frontiers in neurology · 2015Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Hypothalamic fibers containing the wake-promoting peptides, hypocretins (Hcrts) or orexins, provide a dense innervation to the medial septum-diagonal band of Broca (MSDB), a sleep-associated brain region that has been suggested to show intense axonal degeneration in canine narcoleptics. The MSDB, via its cholinergic and GABAergic projections to the hippocampus, controls the hippocampal theta rhythm and associated learning and memory functions. Neurons of the MSDB express very high levels of the Hcrt receptor 2, which is mutated in canine narcoleptics. In the present study, we investigated the electrophysiological effects of Hcrt peptides on septohippocampal cholinergic neurons that were identified in living brain slices of the MSDB using a selective fluorescent marker. Hcrt activation of septohippocampal cholinergic neurons was reversible, reproducible, and concentration dependent and mediated via a direct postsynaptic mechanism. Both Hcrt1 and Hcrt2 activated septohippocampal cholinergic neurons with similar EC(50) values. The Hcrt effect was dependent on external Na(+), reduced by external Ba(2+), and also reduced in recordings with CsCl-containing electrodes, suggesting a dual underlying ionic mechanism that involved inhibition of a K(+) current, presumably an inward rectifier, and a Na(+)-dependent component. The Na(+) component was dependent on internal Ca(2+), blocked by replacing external Na(+) with Li(+), and also blocked by bath-applied Ni(2+) and KB-R7943, suggesting involvement of the Na(+)-Ca(2+) exchanger. Using double-immunolabeling studies at light and ultrastructural levels, we also provide definitive evidence for a hypocretin innervation of cholinergic neurons. Thus Hcrt effects within the septum should increase hippocampal acetylcholine release and thereby promote hippocampal arousal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.