ArticleJournal of clinical microbiology2004
Assessment of the epidemic potential of a new strain of rotavirus associated with the novel G9 serotype which caused an outbreak in the United States for the first time in the 1995-1996 season.
Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 73 citations in OpenAlex.
- Understanding the penetrance of intrinsic protein disorder in rotavirus proteome.International journal of biological macromolecules · 2020Article
- Molecular epidemiology of Rotavirus causing diarrhea among children less than five years of age visiting national level children hospitals, Nepal.BMC pediatrics · 2017Article
- Association of rotavirus strains and severity of gastroenteritis in Indian children.Human vaccines & immunotherapeutics · 2017Article
- Detection and sequencing of rotavirus among sudanese children.The Pan African medical journal · 2017Article
- Correlates of protection against human rotavirus disease and the factors influencing protection in low-income settings.Mucosal immunology · 2015Review
- Rotavirus and norovirus infections among acute gastroenteritis children in Morocco.BMC infectious diseases · 2014Article
- Epidemiology and genetic diversity of rotavirus strains in children with acute gastroenteritis in Lahore, Pakistan.PloS one · 2013Article
- Rotavirus diversity and evolution in the post-vaccine world.Discovery medicine · 2012Review
- Changing patterns of rotavirus genotypes in Turkey.Current microbiology · 2011Article
- Modeling rotavirus strain dynamics in developed countries to understand the potential impact of vaccination on genotype distributions.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- Unexpectedly high burden of rotavirus gastroenteritis in very young infants.BMC pediatrics · 2010Article
- Rapid changes in rotaviral genotypes in Ecuador.Journal of medical virology · 2009Article
- Decline in cases of rotavirus gastroenteritis presenting to The Children's Hospital of Philadelphia after introduction of a pentavalent rotavirus vaccine.Clinical and vaccine immunology : CVI · 2009Article
- Molecular epidemiology of rotavirus in Central and Southeastern Europe.Journal of clinical microbiology · 2007Article
- Symptomatic and subclinical infection with rotavirus P[8]G9, rural Ecuador.Emerging infectious diseases · 2007Article
- Rotavirus and not age determines gastroenteritis severity in children: a hospital-based study.European journal of pediatrics · 2007Article
- G and P genotyping of human rotavirus isolated in a university hospital in Korea: implications for nosocomial infections.Journal of Korean medical science · 2006Article
- Molecular epidemiology of G9 rotaviruses in Taiwan between 2000 and 2002.Journal of clinical microbiology · 2006Article
- Serotype G9 rotavirus infections in adults in Sweden.Journal of clinical microbiology · 2005Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rotavirus causes severe morbidity in developed countries and frequent deaths (> or = 500,000 per year) in less-developed countries. Historically, four serotypes--G1, G2, G3, and G4-have predominated; they are distinguished by one of two surface neutralization antigens (VP7). However, in 1983 and 1984 we described a new rotavirus serotype, designated G9, in five children hospitalized for diarrhea in Philadelphia, Pa. G9 rotavirus was not identified again in the Western Hemisphere until it caused ca. 50% of the rotavirus disease detected in Philadelphia in the 1995-1996 season. This outbreak allowed us to question whether a rotavirus strain completely new to a well-studied community would target either very young infants or older children, cause especially severe disease, or completely displace previously extant serotypes. We observed a significant excess of G9 infections in younger infants (especially in those < 6 months old) that might be attributed to the lack of G9-specific antibodies in mothers. Of further note, six of the seven oldest patients with rotavirus diarrhea were infected with the G9 strains (not significant). However, the age distribution of children with rotavirus did not differ over a 5-year study period regardless of the infecting serotype. Patients with diarrhea associated with G9 strains did not have disease more severe than that caused by the G1, G2, or G3 serotype. G9 strains did not displace the other serotypes but were virtually completely replaced by G1 or G2 serotypes in the three subsequent rotavirus seasons. We conclude that the abrupt appearance of this novel rotavirus serotype did not present a special threat to public health in the community.
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Registered trials
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