Evidence map›Paper›PMID 15070078›Full record

ArticleTransgenic research2004

On the use of post-transcriptional processing elements in transgenes.

C B A Whitelaw, L Hiripi, E Farini, M L Opsahl, Z Bosze

Open access · bronzeAbstract readEvaluation Study
In one paragraph

Article in Transgenic research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

C B A WhitelawDepartment of Gene Expression and Development, Roslin Institute (Edinburgh), Roslin, Midlothian, EH25 9PS, UK. bruce.whitelaw@bbsrc.ac.uk
L Hiripi
E Farini
M L Opsahl
Z Bosze
Roslin Institute · GBAgricultural Biotechnology Institute · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA processing events modulate final productivity of a given transgene. We have evaluated a series of RNA elements for their ability to enhance alpha1-antitrypsin production in mammary cells. Our results indicate the need for a case-by-case assessment of each construct design and the occurrence of gene silencing events in vivo.

Indexed as

RNA Processing, Post-TranscriptionalTransgenesAnimalsGene SilencingGene Transfer TechniquesMiceMice, TransgenicRNATransfectionRNA

Identifiers

PMID15070078
PMCPMC7089212
OpenAlexW2055987000

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.