ArticleWorld journal of gastroenterology2004
Gastro-electric dysrhythm and lack of gastric interstitial cells of cajal.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Unmasking Gastroparesis in Diabetes During Ramadan: Challenges and Management Strategies.Journal of clinical medicine · 2025Review
- Mild diabetes: long-term effects on gastric motility evaluated in rats.International journal of experimental pathology · 2018Article
- Diabetic and idiopathic gastroparesis is associated with loss of CD206-positive macrophages in the gastric antrum.Neurogastroenterology and motility · 2017Article
- Effect of electroacupuncture on gastric interstitial cells of Cajal in a rat model of diabetic gastroparesis.Experimental and therapeutic medicine · 2016Article
- Connexin and pannexin signaling in gastrointestinal and liver disease.Translational research : the journal of laboratory and clinical medicine · 2015Review
- Is Interstitial Cells of Cajal‒opathy Present in Gastroparesis?Journal of neurogastroenterology and motility · 2015Article
- Alterations of colonic contractility in an interleukin-10 knockout mouse model of inflammatory bowel disease.Journal of neurogastroenterology and motility · 2015Article
- Diabetic gastrointestinal motility disorders and the role of enteric nervous system: current status and future directions.Neurogastroenterology and motility · 2014Review
- Disruption of interstitial cells of Cajal networks after massive small bowel resection.World journal of gastroenterology · 2013Article
- Alterations of colonic contractility in long-term diabetic rat model.Journal of neurogastroenterology and motility · 2011Article
- Interstitial cells of Cajal, the Maestro in health and disease.World journal of gastroenterology · 2010Review
- Cellular pathogenesis of diabetic gastroenteropathy.Minerva gastroenterologica e dietologica · 2009Review
- Interstitial cells of Cajal in the gut--a gastroenterologist's point of view.World journal of gastroenterology · 2008Review
- Noninvasive assessment of the effects of glucagon on the gastric slow wave.American journal of physiology. Gastrointestinal and liver physiology · 2007Article
- Myoelectric activity and motility of the Roux limb after cut or uncut Roux-en-Y gastrojejunostomy.World journal of gastroenterology · 2006Article
- A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus.Journal of gastroenterology · 2006Article
- Upper gastrointestinal sensory-motor dysfunction in diabetes mellitus.World journal of gastroenterology · 2006Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe pathophysiology underlying gastrointestinal complications of long-standing diabetes is poorly understood. Recent evidence suggests an important role of intestitial cells of cajal in controlling gastrointestinal motility. The aim of this study was to clarify the changes of ultrastructural characteristics of interstitial cells of cajal in stomach of diabetic gastro-electric dysrhythmic rats.
methodsRats were randomly divided into diabetic group and control group, the model of diabetic rats was established by peritoneally injection of streptozotocin. Electrogastrograms were recorded and intestitial cells of cajal in antrum were observed by electrictelescopy after diabetic model rat was established for 3 mo.
resultsIn the rats of diabetic group, the gastro-electric dysrhythmia was increased compared with control group, the abnormal rhythm index and the cofficient of variation of slow wave frequency were significantly higher than those of normal rats. The number of the gap junctions of interstitial cells of cajal in antrum of diabetic rats was significantly decreased, and the remaining structures were damaged. The organelles were also damaged, and vacuoles were formed.
conclusionIt is possible that changes in ultrastructural characteristics of interstitial cells of cajal in stomach are one of the mechanisms underlying gastro-electric dysrhythm in diabetic rats.
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