ArticleWorld journal of gastroenterology2004
Hepatic progenitor cells in human liver cirrhosis: immunohistochemical, electron microscopic and immunofluorencence confocal microscopic findings.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis.BMC cancer · 2012Pooled it
- Microenvironmental control of the ductular reaction: balancing repair and disease progression.Cell death & disease · 2025Review
- Review
- Elevation of tumour markers TGF-β, MBMC cancer · 2017Article
- Probing the hepatic progenitor cell in human hepatocellular carcinoma.Gastroenterology research and practice · 2013Article
- Embryonic liver fodrin involved in hepatic stellate cell activation and formation of regenerative nodule in liver cirrhosis.Journal of cellular and molecular medicine · 2012Article
- Contributions of new hepatocyte lineages to liver growth, maintenance, and regeneration in mice.Hepatology (Baltimore, Md.) · 2011Article
- Potential applications for cell regulatory factors in liver progenitor cell therapy.The international journal of biochemistry & cell biology · 2011Review
- Hepatic stellate cells' involvement in progenitor-mediated liver regeneration.Laboratory investigation; a journal of technical methods and pathology · 2010Article
- Significance of increased expression of decoy receptor 3 in chronic liver disease.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2009Article
- Clinicopathologic characteristics of intrahepatic cholangiocarcinoma in patients with positive serum a-fetoprotein.World journal of gastroenterology · 2008Article
- Immunohistochemical characterization of hepatic stem cell-related cells in developing human liver.Frontiers of medicine in China · 2007Article
- Ultrastructure of oval cells in children with chronic hepatitis B, with special emphasis on the stage of liver fibrosis: the first pediatric study.World journal of gastroenterology · 2007Article
- Morphological characterization of very small embryonic-like stem cells (VSELs) by ImageStream system analysis.Journal of cellular and molecular medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate whether hepatic progenitor cells (HPC), that reveal the features of oval cells in rodents and small epithelial cells (SEC) in certain human liver disease, were also found in human liver cirrhosis (HLC).
methodsSurgical liver specimens from 20 cases of hepatitis B virus-positive HLC (15 cases containing hepatocellular carcinoma) were investigated by light microscopic immunohistochemistry (LM-IHC). Among them specimens from 15 cases were investigated by electron microscopy (EM) and those from 5 cases by immunofluorencence confocal laser scanning microscopy (ICLSM). Antibodies against cytokeratin 7 and albumin were used and single and/or double labelling were performed respectively.
resultsLM-IHC showed that at the margins of regenerating nodules and in the fibrous septae, a small number of cells in the proliferating bile ductules were positive for CK7 and albumin. At the EM level these HPC were morphologically similar to the SEC described previously, and also similar to the oval cells seen in experimental hepatocarcinogenesis. They were characterized by their small size, oval shape, a high nucleus/cytoplasm ratio, a low organelle content in cytoplasm, and existence of tonofilaments and intercellular junctions. ICLSM revealed that HPC expressed both cytokeratin 7 and albumin.
conclusionHPC with ultrastructural and immunophenotypical features of oval cells, i.e., hepatic stem cell-like cells as noted in other liver diseases, were found in HLC. These findings further support the hypothesis that bipotent hepatic stem cells, that may give rise to biliary epithelial cells and hepatocytes, exist in human livers.
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