ArticleWorld journal of gastroenterology2004
In vitro effects of recombinant human growth hormone on growth of human gastric cancer cell line BGC823 cells.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Effects of recombinant human growth hormone on enterocutaneous fistula patients.World journal of gastroenterology · 2008Trial
- Pharmacological inhibition of tumor anabolism and host catabolism as a cancer therapy.Scientific reports · 2021Article
- The combination of orlistat, lonidamine and 6-diazo-5-oxo-L-norleucine induces a quiescent energetic phenotype and limits substrate flexibility in colon cancer cells.Oncology letters · 2020Article
- Growth Hormone Protects the Intestine Preserving Radiotherapy Efficacy on Tumors: A Short-Term Study.PloS one · 2015Article
- Investigation of gastric cancers in nude mice using X-ray in-line phase contrast imaging.Biomedical engineering online · 2014Article
- Effects of human growth hormone on gonadotropin-releasing hormone neurons in mice.Korean journal of pediatrics · 2010Article
- Effects of recombinant human growth hormone on growth of human gastric carcinoma xenograft model in nude mice.World journal of gastroenterology · 2006Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the effects of recombinant human growth hormone (rhGH) on growth of human gastric cancer cell line in vitro.
methodsExperiment was divided into control group, rhGH group, oxaliplatin (L-OHP) group and rhGH+L-OHP group. Cell inhibitory rate, cell cycle, cell proliferation index (PI) and DNA inhibitory rate of human gastric cancer line BGC823, at different concentrations of rhGH treatment were studied by cell culture, MTT assay and flow cytometry.
resultsThe distinctly accelerated effects of rhGH on multiplication of BGC823 cell line were not found in vitro. There was no statistical significance between rhGH group and control group, or between rhGH+L-OHP group and L-OHP group (P>0.05). The cell growth curve did not rise. Cell inhibitory rate and cells arrested in G(0)-G(1) phase were obviously increased. Meanwhile, cells in S phase and PI were distinctly decreased and DNA inhibitory rate was obviously increased in rhGH+L-OHP group in comparison with control group and rhGH group, respectively (P<0.01). Cell inhibitory rate showed an increasing trend and PI showed a decreasing trend in rhGH+L-OHP group compared with L-OHP group.
conclusionIn vitro rhGH does not accelerate the multiplication of human gastric cancer cells. It may increase the therapeutic efficacy when it is used in combination with anticancer drugs.
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