ReviewJournal of molecular medicine (Berlin, Germany)2004
Ceramide, membrane rafts and infections.
Review in Journal of molecular medicine (Berlin, Germany), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 163 citations in OpenAlex.
- Olipudase alfa for treatment of acid sphingomyelinase deficiency (ASMD): safety and efficacy in adults treated for 30 months.Journal of inherited metabolic disease · 2018Trial
- Using ultrasound and microbubble to enhance the effects of conventional cancer therapies in clinical settings.Cancer metastasis reviews · 2025Review
- Sphingolipid-Induced Bone Regulation and Its Emerging Role in Dysfunction Due to Disease and Infection.International journal of molecular sciences · 2024Review
- Changes in lipid composition of host-derived extracellular vesicles followingMicrobiology spectrum · 2024Article
- The Role of Lipids in the Regulation of Immune Responses.Nutrients · 2023Review
- Accum™ Technology: A Novel Conjugable Primer for Onco-Immunotherapy.Molecules (Basel, Switzerland) · 2022Review
- Sphingomyelin Depletion Inhibits CXCR4 Dynamics and CXCL12-Mediated Directed Cell Migration in Human T Cells.Frontiers in immunology · 2022Article
- Host cell membrane microdomains and fungal infection.Cellular microbiology · 2021Review
- Review
- Bile Goes Viral.Viruses · 2021Review
- Neutral ceramidase is a marker for cognitive performance in rats and monkeys.Pharmacological reports : PR · 2021Article
- The Manifold Roles of Sphingolipids in Viral Infections.Frontiers in physiology · 2021Review
- Nanoscale imaging of bacterial infections by sphingolipid expansion microscopy.Nature communications · 2020Article
- Mannan Enhances IL-12 Production by Increasing Bacterial Uptake and Endosomal Degradation inFrontiers in immunology · 2019Article
- A Comprehensive Review on the Manipulation of the Sphingolipid Pathway by Pathogenic Bacteria.Frontiers in cell and developmental biology · 2019Review
- Visualization of Ceramide-Associated Proteins in Ceramide-Rich Platforms Using a Cross-Linkable Ceramide Analog and Proximity Ligation Assays With Anti-ceramide Antibody.Frontiers in cell and developmental biology · 2019Article
- Sphingomyelin Breakdown in T Cells: Role of Membrane Compartmentalization in T Cell Signaling and Interference by a Pathogen.Frontiers in cell and developmental biology · 2019Review
- Sphingolipids and lipid rafts: Novel concepts and methods of analysis.Chemistry and physics of lipids · 2018Review
- Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics.Scientific reports · 2018Article
- Lipids in the cell: organisation regulates function.Cellular and molecular life sciences : CMLS · 2018Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Distinct domains in the cell membrane, termed rafts, emerge as central for the infection of mammalian cells by many pathogens. Rafts consist of sphingolipids and cholesterol that interact strongly, and thus spontaneously separate from other phospholipids in the cell membrane. Recent studies suggest that at least some pathogens activate the acid sphingomyelinase that releases ceramide in membrane rafts. The generation of ceramide transforms small rafts into a signaling unit and results in the fusion of small rafts to large platforms. Membrane rafts and ceramide-enriched membrane platforms have been shown to mediate internalization of bacteria, viruses and parasites into the host cell, to initiate apoptosis of the host cell upon infection and to regulate the release of cytokines from infected mammalian cells. Furthermore, rafts and ceramide have been implicated in the intracellular trafficking of phagosomes and in the budding of viruses from infected cells. The molecular function of rafts and ceramide-enriched membrane platforms seems to be the re-organization of receptor and intracellular signaling molecules in the cell membrane permitting the interaction of the pathogen with the cell. This suggests that rafts and ceramide-enriched membrane platforms function as central structures involved in the infection of mammalian cells by pathogens and as targets for the development of anti-infective drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.