ArticleThe Journal of clinical investigation2004
DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response.
Article in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 39 citations in OpenAlex.
- CD4+ regulatory T cell responses induced by T cell vaccination in patients with multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2006Trial
- A cell-based drug delivery platform for treating central nervous system inflammation.Journal of molecular medicine (Berlin, Germany) · 2021Article
- Regulation of Astrocyte Functions in Multiple Sclerosis.Cold Spring Harbor perspectives in medicine · 2019Review
- Dynamic regulation of serum aryl hydrocarbon receptor agonists in MS.Neurology(R) neuroimmunology & neuroinflammation · 2017Article
- Bilirubin suppresses Th17 immunity in colitis by upregulating CD39.JCI insight · 2017Article
- Therapeutic effect of ergotope peptides on CIA by down-regulation of inflammatory and Th1/Th17 responses and induction of regulatory T cells.Molecular medicine (Cambridge, Mass.) · 2016Article
- The mechanisms and applications of T cell vaccination for autoimmune diseases: a comprehensive review.Clinical reviews in allergy & immunology · 2014Review
- HSP60 as a target of anti-ergotypic regulatory T cells.PloS one · 2008Article
- Oral and nasal administration of chicken type II collagen suppresses adjuvant arthritis in rats with intestinal lesions induced by meloxicam.World journal of gastroenterology · 2004Article
- Tregs in T cell vaccination: exploring the regulation of regulation.The Journal of clinical investigation · 2004Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ab's to the alpha-chain of the IL-2 receptor (anti-CD25) are used clinically to achieve immunosuppression. Here we investigated the effects of DNA vaccination with the whole CD25 gene on the induction of rat adjuvant arthritis. The DNA vaccine protected the rats and led to a shift in the cytokine profile of T cells responding to disease target antigens from Th1 to Th2. The mechanism of protection was found to involve the induction of an antiergotypic response, rather than the induction of anti-CD25 Ab's. Antiergotypic T cells respond to activation molecules, ergotopes, expressed on syngeneic activated, but not resting, T cells. CD25-derived peptides function as ergotopes that can be recognized by the antiergotypic T cells. Antiergotypic T cells taken from control sick rats did not proliferate against activated T cells and secreted mainly IFN-gamma. In contrast, antiergotypic cells from CD25-DNA-protected rats proliferated against activated T cells and secreted mainly IL-10. Protective antiergotypic T cells were found in both the CD4+ and CD8+ populations and expressed alpha/beta or gamma/delta T cell receptors. Antiergotypic alpha/beta T cells were MHC restricted, while gamma/delta T cells were MHC independent. Thus, CD25 DNA vaccination may induce protection from autoimmunity by inducing a cytokine shift in both the antiergotypic response and the response to the antigens targeted in the disease.
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