ArticleThe Journal of clinical investigation2004
The immune response to AIDS virus infection: good, bad, or both?
Article in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Trial
- Plasma levels of soluble CD14 independently predict mortality in HIV infection.The Journal of infectious diseases · 2011Trial
- Kaposi's Sarcoma: A Non-Communicable Outcome Mainly Prompted by Communicable Diseases in Sub-Saharan Africa.International journal of molecular sciences · 2025Review
- Comparative Transcriptomic Analysis Revealed Potential Differential Mechanisms of Grass Carp Reovirus Pathogenicity.International journal of molecular sciences · 2023Article
- Computational investigation of benzalacetophenone derivatives against SARS-CoV-2 as potential multi-target bioactive compounds.Computers in biology and medicine · 2022Article
- Unmapped exome reads implicate a role for Anelloviridae in childhood HIV-1 long-term non-progression.NPJ genomic medicine · 2021Article
- A targeted reactivation of latent HIV-1 using an activator vector in patient samples from acute infection.EBioMedicine · 2020Article
- Personal and Clinical Vaginal Lubricants: Impact on Local Vaginal Microenvironment and Implications for Epithelial Cell Host Response and Barrier Function.The Journal of infectious diseases · 2019Article
- Pathophysiology of CD4+ T-Cell Depletion in HIV-1 and HIV-2 Infections.Frontiers in immunology · 2017Review
- Inflammation and Fibrosis in HIV: Getting to the Heart of the Matter.Circulation. Cardiovascular imaging · 2016Article
- Imaging atherosclerotic burden and inflammation: insights into the spectrum of atherosclerotic disease in HIV.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Macropinocytosis and TAK1 mediate anti-inflammatory to pro-inflammatory macrophage differentiation by HIV-1 Nef.Cell death & disease · 2014Article
- Mucosal immunology of HIV infection.Immunological reviews · 2013Review
- Increased T-cell activation and Th1 cytokine concentrations prior to the diagnosis of B-cell lymphoma in HIV infected patients.Journal of clinical immunology · 2013Article
- The HIV-1 protease inhibitor nelfinavir activates PP2 and inhibits MAPK signaling in macrophages: a pathway to reduce inflammation.Journal of leukocyte biology · 2012Article
- Preservation HIV-1-specific IFNγ+ CD4+ T-cell responses in breakthrough infections after exposure to tenofovir gel in the CAPRISA 004 microbicide trial.Journal of acquired immune deficiency syndromes (1999) · 2012Article
- Glances in Immunology of HIV and HCV Infection.Advances in virology · 2012Article
- A plasma biomarker signature of immune activation in HIV patients on antiretroviral therapy.PloS one · 2012Article
- Sex differences in HIV RNA level and CD4 cell percentage during childhood.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2011Article
- Impairment of CD1d-restricted natural killer T cells in chronic HIV type 1 clade C infection.AIDS research and human retroviruses · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A potent antigen-specific T cell response to HIV infection can contribute to the control of viral replication and is therefore beneficial to the host. However, HIV-mediated increases in generalized T cell activation also appear to accelerate both viral replication and CD4+ T cell depletion. A new study in the JCI attempts to experimentally distinguish the beneficial versus harmful aspects of this immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.