ArticleThe Journal of cell biology2004
Ca(2+)(cyt) negatively regulates the initiation of oocyte maturation.
Article in The Journal of cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- Mitochondria-ER contact sites expand during mitosis.iScience · 2024Article
- A localized calcium transient and polar body abscission.Cell cycle (Georgetown, Tex.) · 2022Article
- Neurotransmitters, neuropeptides and calcium in oocyte maturation and early development.Frontiers in cell and developmental biology · 2022Review
- Lipid Signaling During Gamete Maturation.Frontiers in cell and developmental biology · 2022Review
- Remodeling of ER-plasma membrane contact sites but not STIM1 phosphorylation inhibits CaProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Changes in CaFrontiers in physiology · 2019Article
- Effect of Kisspeptin on the Developmental Competence and Early Transcript Expression in Porcine Oocytes Parthenogenetically Activated with Different Methods.BioMed research international · 2018Article
- Spindle function in Xenopus oocytes involves possible nanodomain calcium signaling.Molecular biology of the cell · 2016Article
- Differential role of STIM1 and STIM2 during transient inward (T in) current generation and the maturation process in the Xenopus oocyte.BMC physiology · 2014Article
- Insights into molecular features of Venerupis decussata oocytes: a microarray-based study.PloS one · 2014Article
- Ca2+ influx and the store-operated Ca2+ entry pathway undergo regulation during mouse oocyte maturation.Molecular biology of the cell · 2013Article
- Dynamic analysis of Ca²+ level during bovine oocytes maturation and early embryonic development.Journal of veterinary science · 2011Article
- Article
- Ca(2+) signaling, genes and the cell cycle.Cell calcium · 2010Review
- Calcium dynamics during physiological acidification in Xenopus oocyte.The Journal of membrane biology · 2010Article
- Regulation of store-operated Ca2+ entry during the cell cycle.Journal of cell science · 2010Article
- Orai1 internalization and STIM1 clustering inhibition modulate SOCE inactivation during meiosis.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Kinase-dependent regulation of inositol 1,4,5-trisphosphate-dependent Ca2+ release during oocyte maturation.The Journal of biological chemistry · 2009Article
- Internalization of plasma membrane Ca2+-ATPase during Xenopus oocyte maturation.Developmental biology · 2008Article
- Ca2+ homeostasis regulates Xenopus oocyte maturation.Biology of reproduction · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ca(2+) is a ubiquitous intracellular messenger that is important for cell cycle progression. Genetic and biochemical evidence support a role for Ca(2+) in mitosis. In contrast, there has been a long-standing debate as to whether Ca(2+) signals are required for oocyte meiosis. Here, we show that cytoplasmic Ca(2+) (Ca(2+)(cyt)) plays a dual role during Xenopus oocyte maturation. Ca(2+) signals are dispensable for meiosis entry (germinal vesicle breakdown and chromosome condensation), but are required for the completion of meiosis I. Interestingly, in the absence of Ca(2+)(cyt) signals oocytes enter meiosis more rapidly due to faster activation of the MAPK-maturation promoting factor (MPF) kinase cascade. This Ca(2+)-dependent negative regulation of the cell cycle machinery (MAPK-MPF cascade) is due to Ca(2+)(cyt) acting downstream of protein kinase A but upstream of Mos (a MAPK kinase kinase). Therefore, high Ca(2+)(cyt) delays meiosis entry by negatively regulating the initiation of the MAPK-MPF cascade. These results show that Ca(2+) modulates both the cell cycle machinery and nuclear maturation during meiosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.