ArticleApplied and environmental microbiology2004
Genome shuffling improves degradation of the anthropogenic pesticide pentachlorophenol by Sphingobium chlorophenolicum ATCC 39723.
Article in Applied and environmental microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 156 citations in OpenAlex.
- XenoBug: machine learning-based tool to predict pollutant-degrading enzymes from environmental metagenomes.NAR genomics and bioinformatics · 2025Article
- Development of a RobustMicroorganisms · 2024Article
- Whole-genome sequencing, genome mining, metabolic reconstruction and evolution of pentachlorophenol and other xenobiotic degradation pathways in Bacillus tropicus strain AOA-CPS1.Functional & integrative genomics · 2021Article
- Use of Permanent Wall-Deficient Cells as a System for the Discovery of New-to-Nature Metabolites.Microorganisms · 2020Article
- Applications and research advance of genome shuffling for industrial microbial strains improvement.World journal of microbiology & biotechnology · 2020Review
- Potential Applications of Clay-Based Therapy for the Reduction of Pesticide Exposures in Humans and Animals.Applied sciences (Basel, Switzerland) · 2019Article
- Genome shuffling improved acid-tolerance and succinic acid production ofFood science and biotechnology · 2019Article
- Enhanced production of tanshinone IIA in endophytic fungi Emericella foeniculicola by genome shuffling.Pharmaceutical biology · 2018Article
- Genome shuffling and high-throughput screening of Brevibacterium flavum MDV1 for enhanced L-valine production.World journal of microbiology & biotechnology · 2018Article
- Biodegradation of phenol and its derivatives by engineered bacteria: current knowledge and perspectives.World journal of microbiology & biotechnology · 2017Review
- The Biodiversity Changes in the Microbial Population of Soils Contaminated with Crude Oil.Current microbiology · 2016Article
- Advances in Microfluidic Paper-Based Analytical Devices for Food and Water Analysis.Micromachines · 2016Review
- Biodegradation of hexachlorobenzene by a constructed microbial consortium.World journal of microbiology & biotechnology · 2015Article
- Deconstructing the genetic basis of spent sulphite liquor tolerance using deep sequencing of genome-shuffled yeast.Biotechnology for biofuels · 2015Article
- Xylose-fermenting Pichia stipitis by genome shuffling for improved ethanol production.Microbial biotechnology · 2014Article
- Biodegradation of di-n-butyl phthalate by a newly isolated halotolerant Sphingobium sp.International journal of molecular sciences · 2013Article
- Streptomycin resistance-aided genome shuffling to improve doramectin productivity of Streptomyces avermitilis NEAU1069.Journal of industrial microbiology & biotechnology · 2013Article
- Sequestration of a highly reactive intermediate in an evolving pathway for degradation of pentachlorophenol.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Improved ethanol production by a xylose-fermenting recombinant yeast strain constructed through a modified genome shuffling method.Biotechnology for biofuels · 2012Article
- Genome shuffling of Bacillus amyloliquefaciens for improving antimicrobial lipopeptide production and an analysis of relative gene expression using FQ RT-PCR.Journal of industrial microbiology & biotechnology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pentachlorophenol (PCP), a highly toxic anthropogenic pesticide, can be mineralized by Sphingobium chlorophenolicum, a gram-negative bacterium isolated from PCP-contaminated soil. However, degradation of PCP is slow and S. chlorophenolicum cannot tolerate high levels of PCP. We have used genome shuffling to improve the degradation of PCP by S. chlorophenolicum. We have obtained several strains that degrade PCP faster and tolerate higher levels of PCP than the wild-type strain. Several strains obtained after the third round of shuffling can grow on one-quarter-strength tryptic soy broth plates containing 6 to 8 mM PCP, while the original strain cannot grow in the presence of PCP at concentrations higher than 0.6 mM. Some of the mutants are able to completely degrade 3 mM PCP in one-quarter-strength tryptic soy broth, whereas no degradation can be achieved by the wild-type strain. Analysis of several improved strains suggests that the improved phenotypes are due to various combinations of mutations leading to an enhanced growth rate, constitutive expression of the PCP degradation genes, and enhanced resistance to the toxicity of PCP and its metabolites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.