ArticleApplied and environmental microbiology2004
Genetic markers unique to Listeria monocytogenes serotype 4b differentiate epidemic clone II (hot dog outbreak strains) from other lineages.
Article in Applied and environmental microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Using genome-scale metabolic models to compare serovars of the foodborne pathogen Listeria monocytogenes.PloS one · 2018Article
- It Is Not All about Single Nucleotide Polymorphisms: Comparison of Mobile Genetic Elements and Deletions in Listeria monocytogenes Genomes Links Cases of Hospital-Acquired Listeriosis to the Environmental Source.Journal of clinical microbiology · 2015Article
- Effector bottleneck: microbial reprogramming of parasitized host cell transcription by epigenetic remodeling of chromatin structure.Frontiers in genetics · 2014Review
- "Epidemic clones" of Listeria monocytogenes are widespread and ancient clonal groups.Journal of clinical microbiology · 2013Article
- Molecular approaches to the identification of pathogenic and nonpathogenic listeriae.Microbiology insights · 2013Review
- A novel restriction-modification system is responsible for temperature-dependent phage resistance in Listeria monocytogenes ECII.Applied and environmental microbiology · 2012Article
- Atypical Listeria monocytogenes serotype 4b strains harboring a lineage II-specific gene cassette.Applied and environmental microbiology · 2012Article
- Worldwide distribution of major clones of Listeria monocytogenes.Emerging infectious diseases · 2011Article
- Prevalence of Listeria monocytogenes in raw meats marketed in Bangkok and characterization of the isolates by phenotypic and molecular methods.Journal of health, population, and nutrition · 2011Article
- A targeted multilocus genotyping assay for lineage, serogroup, and epidemic clone typing of Listeria monocytogenes.Applied and environmental microbiology · 2010Article
- DNA probes for unambiguous identification of Listeria monocytogenes epidemic clone II strains.Applied and environmental microbiology · 2010Article
- Differential Listeria monocytogenes strain survival and growth in Katiki, a traditional Greek soft cheese, at different storage temperatures.Applied and environmental microbiology · 2009Article
- Temperature-dependent phage resistance of Listeria monocytogenes epidemic clone II.Applied and environmental microbiology · 2009Article
- Faecal shedding and strain diversity of Listeria monocytogenes in healthy ruminants and swine in Northern Spain.BMC veterinary research · 2009Article
- Multiple-locus variable-number tandem-repeat analysis as a tool for subtyping Listeria monocytogenes strains.Journal of clinical microbiology · 2008Article
- Absence of serotype-specific surface antigen in laboratory variants of epidemic-associated Listeria monocytogenes strains.Applied and environmental microbiology · 2007Article
- Multiplex PCR for simultaneous detection of bacteria of the genus Listeria, Listeria monocytogenes, and major serotypes and epidemic clones of L. monocytogenes.Applied and environmental microbiology · 2007Article
- Multiplex PCR for the identification and serotyping of L. monocytogenes isolated from sheep cheese-processing plants.Veterinary research communications · 2007Article
- Multi-virulence-locus sequence typing identifies single nucleotide polymorphisms which differentiate epidemic clones and outbreak strains of Listeria monocytogenes.Journal of clinical microbiology · 2007Article
- A single-nucleotide-polymorphism-based multilocus genotyping assay for subtyping lineage I isolates of Listeria monocytogenes.Applied and environmental microbiology · 2007Article
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8 authors.
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Abstract
A small number of closely related strains of Listeria monocytogenes serotype 4b, designated epidemic clone I (ECI), have been implicated in numerous outbreaks of food-borne listeriosis described during the past two decades in Europe and North America. In 1998 to 1999, a multistate outbreak traced to contaminated hot dogs involved a different strain type of serotype 4b, with genetic fingerprints rarely encountered before. In spite of the profound economic and public health impact of this outbreak, the implicated bacteria (designated epidemic clone II [ECII]) have remained poorly characterized genetically, and nucleotide sequences specific for these strains have not been reported. Using genome sequence information, PCR, and Southern blots, we identified DNA fragments which appeared to be either absent or markedly divergent in the hot dog outbreak strains but conserved among other serotype 4b strains. PCR with primers derived from these fragments as well as Southern blots with the amplicons as probes readily differentiated ECII from other serotype 4b strains. The serotype 4b-specific region harboring these fragments was adjacent to inlA, which encodes a well-characterized virulence determinant. The findings suggest that ECII strains have undergone divergence in portions of a serotype-specific region that is conserved in other serotype 4b strains. Although the mechanisms that drive this divergence remain to be identified, DNA-based tools from this region can facilitate the detection and further characterization of strains belonging to this lineage.
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