ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2004
Meiotic recombination hot spots and human DNA diversity.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Article
- PRDM9 drives the location and rapid evolution of recombination hotspots in salmonid fish.PLoS biology · 2025Article
- Rapid Evolution of the Fine-scale Recombination Landscape in Wild House Mouse (Mus musculus) Populations.Molecular biology and evolution · 2023Article
- Mining and analysis of microsatellites in human coronavirus genomes using the in-house built Java pipeline.Genomics & informatics · 2022Article
- Speciation of Genes and Genomes: Conservation of DNA Polymorphism by Barriers to Recombination Raised by Mismatch Repair System.Frontiers in genetics · 2022Review
- Genetic variation in recombination rate in the pig.Genetics, selection, evolution : GSE · 2021Article
- Genome diversity and instability in human germ cells and preimplantation embryos.Seminars in cell & developmental biology · 2021Article
- Evolutionary dynamics of the human pseudoautosomal regions.PLoS genetics · 2021Article
- Haplotype Shuffling and Dimorphic Transposable Elements in the Human Extended Major Histocompatibility Complex Class II Region.Frontiers in genetics · 2021Article
- SNP-Density Crossover Maps of Polymorphic Transposable Elements and HLA Genes Within MHC Class I Haplotype Blocks and Junction.Frontiers in genetics · 2020Article
- A rigorous measure of genome-wide genetic shuffling that takes into account crossover positions and Mendel's second law.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Recombination hotspots in an extended human pseudoautosomal domain predicted from double-strand break maps and characterized by sperm-based crossover analysis.PLoS genetics · 2018Article
- The Red Queen model of recombination hot-spot evolution: a theoretical investigation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- The Role of Microsatellites in Streptophyta Gene Evolution.Journal of molecular evolution · 2017Article
- Commercial chicken breeds exhibit highly divergent patterns of linkage disequilibrium.Heredity · 2016Article
- Whole genome sequences are required to fully resolve the linkage disequilibrium structure of human populations.BMC genomics · 2015Article
- Specific modifications of histone tails, but not DNA methylation, mirror the temporal variation of mammalian recombination hotspots.Genome biology and evolution · 2014Article
- Inferring outcrossing in the homothallic fungus Sclerotinia sclerotiorum using linkage disequilibrium decay.Heredity · 2014Article
- Recombination in the human Pseudoautosomal region PAR1.PLoS genetics · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meiotic recombination plays a key role in the maintenance of sequence diversity in the human genome. However, little is known about the fine-scale distribution and processes of recombination in human chromosomes, or how these impact on patterns of human diversity. We have therefore developed sperm typing systems that allow human recombination to be analysed at very high resolution. The emerging picture is that human crossovers are far from randomly distributed but instead are targeted into very narrow hot spots that can profoundly influence patterns of haplotype diversity in the human genome. These hot spots provide fundamental information on processes of human crossover and gene conversion, as well as evidence that they can violate basic rules of Mendelian inheritance.
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