ReviewJournal of clinical laboratory analysis2004
Reference distributions for alpha2-macroglobulin: a comparison of a large cohort to the world's literature.
Review in Journal of clinical laboratory analysis, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reference distributions for apolipoproteins AI and B and B/AI ratios: comparison of a large cohort to the world's literature.Journal of clinical laboratory analysis · 2006Pooled it
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- The kinetics and interplay of thrombin inhibition by 4 plasma proteinase inhibitors.Blood vessels, thrombosis & hemostasis · 2025Article
- Article
- COVID-19-associated coagulopathy-Hypothesis: Are children protected due to enhanced thrombin inhibition by higher αJournal of thrombosis and haemostasis : JTH · 2020Article
- Alpha2-macroglobulin as a promising biomarker for cerebral small vessel disease in acute ischemic stroke patients.Journal of neurology · 2013Article
- Reference distributions for alpha2-macroglobulin: a practical, simple and clinically relevant approach in a large cohort.Journal of clinical laboratory analysis · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lack of satisfactory methods for quantifying serum levels and a credible reference material has limited bedside use of serum alpha(2)-macroglobulin (alpha2M) measurements. Great strides have been made in the last few years. The remaining barrier to more relevant and cost effective use of serum protein data for diagnosis and prognosis is the availability of reliable reference intervals from birth to old age for both males and females. A total of 40 publications reporting reference intervals have been identified that meet the criteria used in our prior five studies, and these have been analyzed statistically. On average, previous small studies of these individual proteins agree with our life-long reference ranges over their constrained age ranges. This meta-analysis provides support for our reference ranges and places them in the perspective of previous publications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.